Chlorothiazide (Diuril) was synthesized by Novello and Sprague, who also reported on its diuretic properties.’ Pharmacological studies in animals revealed that the orally administered drug produced a marked increase in the urinary excretion of sodium, potassium, and chloride.” No evidence of tolerance developed on continued administration. Ford and Moyer and their co-workers confirmed in man th...

Sodium is an important cation and has an important role in BP regulation and ECF balance. Kidney plays an important role in sodium balance. Almost 99% of filtered sodium is reabsorbed. The absorption occurs via sodium transporters located in the various segments of the nephron. Each of these transporters has unique features and is blocked by a specific diuretic. The activating and inactivating ...

Background-Treatment with diuretics has been reported to increase the risk of arrhythmic death in patients with hypertension. The effect of diuretic therapy on arrhythmic death in patients with left ventricular dysfunction is unknown. Methods and Results-We conducted a retrospective analysis of 6797 patients with an ejection fraction <0.36 enrolled in the Studies Of Left Ventricular Dysfunction...

With numerous safe and effective antihypertensive drugs now available, the clinician should no longer choose only diuretic agents or /3-adrenergic receptor blockers (/3-blockers) as initial therapy. Five classes of agents, including angiotensin converting enzyme inhibitors, /3-blockers, calcium entry blockers, peripheral a,-adrenergic receptor blockers, and thiazide diuretic agents, are all app...

Effects of an adenosine A1-receptor agonist and antagonist were determined in pertussis toxin (IAP)-treated and non-treated rats. (-)-N6-(2-phenylisopropyl) adenosine, an adenosine A1-agonist, reduced the urine volume and sodium excretion without decreasing the glomerular filtration rate at 0.1 mg/kg (p.o.) in both IAP-treated and non-treated rats. Diuretic effects of KW-3902 (8-(noradamantan-3...

indacrinone is a loop diuretic which also has uricosuric, kaliuretic, saliuretic and natriuretic effects. since it has been reported that this drug has several actions in different organs, we decided to evaluate its mechanism of action on the rat jejunum smooth muscle. after preparation of the tissues, different concentrations of indacrinone were applied. doses of 8.2×10^-6 m, 2.7×10^-5 m, 8.2×...

Introduction: It has been suggested that calculation of differential renal function (DRF) using 99mTc-DMSA may lead to overestimation of the function of an obstructed kidney. The aim of this study was to evaluate the effect of diuretic administration on the determination of DRF using 99mTc-DMSA scintigraphy in patients with dilated pelvis. Methods: Thirty three patients, aged from 2 month...

Renotropic Characteristics of Ethacrynic Acid: A Phenoxyacetic Saluretic-Diuretic Agent. KARL H. BEYER, JOHN E. BAER, JOAN K. MICRAELSON AND HORACE F. Russo 1 A Cellular Action of Mercurial Diuretics. VERNON D. JONES, GEORGE L0CKETT AND ERWIN J. LANDON 23 The Saluretic Effects of Arecoline Hydrochloride Infused into the Left Renal Artery of Dogs. RONALD L. WILLIAMS, JAMES E. PEARSON, JR. AND M....