The objective of this study was to evaluate and compare the effect of four superdisintegrants such as croscarmellose sodium (Ac-Di-Sol), crospovidone (Kollidon CL and with smaller particle sizes Kollidon CL-F), sodium starch glycolate (Explotab) in combination with β-lactose and microcrystalline cellulose (Avicel PH-102) as base excipients exhibiting properties of directly compressed tablets an...

We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy (PLM) and a small-scale dissolution apparatus (μDISS Profiler) to investigate the mechanism (solid-to-solid or solution-mediated) by which crystallization of amorphous drugs occurs upon dissolution. This protocol then guided how to stabilize ...

A reactive fluid dissolving the surface of a uniform fracture will trigger an instability in the dissolution front, leading to spontaneous formation of pronounced well-spaced channels in the surrounding rock matrix. Although the underlying mechanism is similar to the wormhole instability in porous rocks there are significant differences in the physics, due to the absence of a steadily propagati...

Cytosolic compartmentalization through liquid-liquid unmixing, such as the formation of RNA granules, is involved in many cellular processes and might be used to regulate signal transduction. However, specific molecular mechanisms by which liquid-liquid unmixing and signal transduction are coupled remain unknown. Here, we show that during cellular stress the dual specificity kinase DYRK3 regula...

Tubular ZnO microstructural arrays were fabricated by a hydrothermal decomposition method. The dependence of the morphologies on the growth time and temperature was investigated in detail. An experiment was carried out to determine the mechanism of tubular ZnO formation. Our results showed that ZnO microtubes originated from an ageing process from ZnO microrods at a lower temperature (compared ...

Dissolution of calcite in the presence of phosphate solutions was studied in situ by Atomic Force Microscopy. Results of experiments in slightly alkaline (NH4)2HPO4 solutions showed that dissolution, measured from etch pit spreading, is significantly reduced compared to that observed in pure deionized water, confirming an inhibitory effect of (NH4)2HPO4 on calcite dissolution. However, rates me...

In the present study, asymmetric membrane capsules (AMCs) with two compartments were successfully developed for simultaneous delivery of two poorly water-soluble drugs, Atenolol and Amlodipine Besylate, by using solubility modulation approach. Scanning electron microscopy (SEM) before dissolution showed presence of outer dense region and inner porous region for the prepared asymmetric membrane ...

We have presented a mechanism to explain why the resulting oxide morphology becomes a porous or a tubular nanostructure when a zircaloy is electrochemically anodized. A porous zirconium oxide nanostructure is always formed at an initial anodization stage, but the degree of interpore dissolution determines whether the final morphology is nanoporous or nanotubular. The interpore dissolution rate ...

Objective: The objective of the present investigation was to improve dissolution characteristics of EZE, which might offer improved bioavailability. Method: The solid dispersion of Ezetimibe was prepared by Solvent evaporation method by using 1:1, 1:2 and 1:3 ratios of drug and polymers (PVP K-30, Sodium starch glycolate). The tablets were prepared by direct compression method. The compressed t...

As a method to reduce atmospheric emissions of carbon dioxide (CO2), this greenhouse gas can be separated at large point-sources, compressed and injected into geological formations such as saline aquifers. Several physical features of the fluids and the rock sequester the CO2 in the pores of the rock for geologic time-scales. One such feature is dissolution into the brine, which increases the d...