Various substituted Dispiro [pyrrolo-piperazino-oxindole] have been synthesized by utilizing a simple and efficient two-step synthetic protocol Grubbs metathesis in dichloromethane at 40°C. The structures relative stereochemistry of the cycloadduct were confirmed single-crystal X-ray diffraction, 1H 13C NMR spectroscopy, mass spectrometry.
 
 Keywords: Hexahydro-diazecane-dione, Metat...

Abstract The synthesis of bench‐stable electrophilic thiocyanating reagents was depicted in two steps from readily available starting materials good yields. These newly designed were successfully applied for the thiocyanation different nucleophiles under mild and transition metal‐free conditions. Preliminary experiments asymmetric C3‐thiocyanation an oxindole derivative also conducted leading t...

The primary aim of this work was to determine the interactions of an oxindole alkaloid (mitraphylline) isolated from Uncaria tomentosa with beta-amyloid 1-40 (Abeta1-40 protein) applying the capillary electrophoresis (CE) method. Specifically the Hummel-Dreyer method and Scatchard analysis were performed to study the binding of oxindole alkaloids with Abeta1-40 protein. Prior to these studies e...