Nuclear acetyltransferases promote and deacetylases inhibit skeletal muscle-gene expression, suggesting the potential effectiveness of deacetylase inhibitors (DIs) in modulating skeletal myogenesis. Surprisingly, previous studies have indicated that DIs suppress myogenesis. The recent observations that histone deacetylases associate with the muscle-regulatory proteins MyoD and MEF2C only in und...

INTRODUCTION Daily interruption of sedation (DIS) and sedation algorithms (SAs) have been shown to decrease mechanical ventilation (MV) duration. We conducted a randomized study comparing these strategies. METHODS Mechanically ventilated adults 18 years old or older in the medical intensive care unit (ICU) were randomly assigned to DIS or SA. Exclusion criteria were severe neurocognitive dysf...

Abstract There has been a profusion of institutionalized practices confiscation and destruction migrants’ belongings during European bordering operations conducted by the police border authorities. Clothes, shoes, money, food, mobile phones, even water have among items seized authorities, practice that exposes migrants to multiple risks. That said, despite pervasiveness current (dis)possessive ...

This paper describes properties of normal dis uent speech which help listeners to distinguish dis uent from uent strings of speech. It focusses on juncture phenomena in cases where there is no clear silent pause at the interruption point. Recent attempts to de ne acoustically identi able features of speech which can be seen as reliable indicators of dis uency have produced several suggestions. ...

BACKGROUND Depressive thoughts are known to persist in persons with depressed mood leading to rumination and exacerbation of depressive symptoms. What has not yet been examined is whether this persistence of depressive thoughts can lead to impairment of working memory (WM). METHODS We assessed whether receiving a WM task featuring depressive cues could bias performance on a subsequent, non-de...

Let us dream of e-Uranium DIS at THERA at Q ∼ 10 GeV and x ∼ 10. Violent DIS is associated with complete destruction of the target, deposition of a mere dozen MeV energy breaks the uranium nucleus entirely, yet a rigorous prediction from unitarity is that diffractive DIS eU → eXU with the target nucleus emerging intact in the ground state will make≈ 50% of total DIS ! By the Glauber-Gribov theo...

AIM Dissociative symptoms are often found in psychiatric patients and have been implicated in psychotic trauma. We aimed to explore dissociative tendencies in psychiatric patients including dissociative disorders (DDs), obsessive-compulsive disorder (OCD), eating disorder (ED), and post-traumatic stress disorder (PTSD) by using the Dissociation Questionnaire Japanese version (DIS-Q-J). METHOD...