Diphtheria is a severe infection, with high mortality rate and affects the upper respiratory tract. Transmission by direct contact/sneezing/coughing may lead to myocarditis, peripheral neuropathy, pneumonia or failure. This watching brief aims describe epidemiology of recent 2022 diphtheria outbreak among migrants in Europe identify key factors that aid future control measures. 
 It was se...

PURPOSE Active reduced dose tetanus-diphtheria-acellular pertussis (Tdap) vaccination for adolescents and adults is necessary because waning immunity after primary diphtheria-tetanus-pertussis vaccination is related to the recent emergence of pertussis. This study was conducted to compare the immunogenicity and protection efficacy against Bordetella pertussis between a new GCC Tdap vaccine and ...

BACKGROUND The risk of immune thrombocytopenic purpura (ITP) after childhood vaccines other than measles-mumps-rubella vaccine (MMR) is unknown. METHODS Using data from 5 managed care organizations for 2000 to 2009, we identified a cohort of 1.8 million children ages 6 weeks to 17 years. Potential ITP cases were identified by using diagnostic codes and platelet counts. All cases were verified...

Purpose - to study the state of protection against vaccine-controlled infections in children with primary immunodeficiency (PID) and on immunosuppressive therapy. Materials methods. The object was level intensity humoral immunity viral (measles, rubella) bacterial (diphtheria, tetanus) immunosuppressed patients. Protective levels specific IgG antibodies vaccine antigens were determined 58 20 re...

The introduction of combination vaccines plays a significant role in increasing vaccine acceptance and widening vaccine coverage. Primary vaccination against diphtheria, tetanus, pertussis, poliomyelitis and Haemophilus influenza type b (Hib) diseases has been implemented in Vietnam. In this study we evaluated the safety and reactogenicity of combined diphtheria-tetanus-pertussis-inactivated po...

and Acellular Pertussis Vaccine Adsorbed Combined with Inactivated Poliovirus Vaccine) Compared to DAPTACEL 1 (Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed) + IPOL 1 (Poliovirus Vaccine Inactivated) as the 5th Dose in Children 4 to 6 Years of Age Michael Smith, MD; Xiaohua Sheng, PhD; Emilia Jordanov, MD; Peter Tsang, MD PhD; Louisville University, Louisville, KY; Cli...

The vaccine developed for pneumococcal diseases is a heptavalent conjugate vaccine (PCV 7). This particular vaccine consists of capsular polysaccharides originated from seven different Streptococcus pneumoniae species along with the protein diphtheria crm197 as conjugate antigens. In a month time after inoculation in children this vaccine is able to increase the IgG level sufficiently to combat...

AIM We studied the effect on neurodevelopment of infants who are exposed to thimerosal in tetanus-diphtheria (Td) vaccines during pregnancy. METHODS We compared Gesell Developmental Schedules (GDS) of exclusive breastfed infants at 6 months born to mothers who received Td (1 to 3 doses) against those who were born to mothers who did not take such vaccines. RESULTS Compared with the group of...

background and objective: escherichia coli o157:h7, an emerging pathogen, causes severe enteritis and the extraintestinal complication of hemolytic-uremic syndrome. the goal of this study was to evaluate the conjugate of e. coli o157: h7 lipopolysaccharide (lps) with diphtheria toxoid (dt) as a candidate vaccine in mice model. material and methods: lps from e. coli o157:h7 was extracted by hot ...

The cytotoxicity (TD) level of diphtheria toxin for human Chang liver strain was 0.1 guinea pig MLD per ml; for mouse liver NCTC 1469 strain, the TD was 500 MLD per ml. The results of cell culture toxicity correlated well with relative susceptibility of both man and mouse. The initial effects of toxin on the susceptible Chang liver cells were studied at one half the TD level (0.05 MLD per ml). ...