New data are reported for the mass-spectrometry fragmentation patterns of helium clusters, either pure or containing a Ne or an Ar atom. The patterns for He(n)+ and Ar+He(n) show clear evidence of structure, while those of Ne+He(n) do not. To better understand the surprising result for the Ne+He(n) fragments, diffusion quantum Monte Carlo (DMC) calculations of the energies and structural proper...

The Hilbert space of an RSOS-model, introduced by Andrews, Baxter, and Forrester, can be viewed as a space of sequences (paths) {a0, a1, . . . , aL}, with aj-integers restricted by 1 ≤ aj ≤ ν, | aj − aj+1 |= 1, a0 ≡ s, aL ≡ r. In this paper we introduce different basis which, as shown here, has the same dimension as that of an RSOS-model. This basis appears naturally in the Bethe ansatz calcula...

We define a Cartesian product G ×H for finite simple graphs which satisfies the Künneth formula H(G × H) = ⊕i+j=kH(G) ⊗ H(G) and so pG×H(x) = pG(x)pH(y) for the Poincaré polynomial pG(x) = ∑ k=0 dim(H (G))x and χ(G × H) = χ(G)χ(H) for the Euler characteristic χ(G) = pG(−1). The graph G1 = G × K1 is homotopic to G, has a digraph structure and satisfies the inequality dim(G1) ≥ dim(G) and G1. Hod...

Two populations of human natural killer (NK) cells can be identified in peripheral blood. The majority are CD3(-)CD56(dim) cells while the minority exhibits a CD3(-)CD56(bright) phenotype. In vitro evidence indicates that CD56(bright) cells are precursors of CD56(dim) cells, but in vivo evidence is lacking. Here, we studied NK cells from a patient that suffered from a melanoma and opportunistic...

We have completed a single ascending dose clinical study of the proposed chemopreventive agent 3,3'-diindolylmethane (DIM). The study agent was nutritional-grade, absorption-enhanced BioResponse 3,3'-diindolylmethane (BR-DIM). We determined the safety, tolerability, and pharmacokinetics of single doses of BR-DIM in drug-free, non-smoking, healthy men and women. Groups of four subjects were enro...

3,3'-Diindolylmethane (DIM) is a stable condensation product of indole-3-carbanol, a potential breast cancer chemoprevention agent. Human breast cancer cell lines were studied to better understand its mechanisms. In vitro experiments were done in MCF-7, T47D, BT-20 and BT-474 cells using MTT, ELISA, immunoblotting assays, reverse transcription-PCR, protein half-life, confocal microscopy, cell f...

Progression of prostate cancer is believed to be dependent on angiogenesis induced by tumor cells. 3,3¶-Diindolylmethane (DIM) has been shown to repress neovascularization in a Matrigel plug assay and inhibit cell proliferation, migration, invasion, and capillary tube formation of cultured human umbilical vein endothelial cells. However, the molecular mechanism, by which DIM inhibits angiogenes...

We have isolated a recessive mutation named diminuto (dim) from T-DNA transformed lines of Arabidopsis thaliana. Under normal growth conditions, the dim mutant has very short hypocotyls, petioles, stems, and roots because of the reduced size of cells along the longitudinal axes of these organs. In addition, dim results in the development of open cotyledons and primary leaves in dark-grown seedl...

Most bees forage for floral resources during the day, but temporal patterns of foraging activity vary extensively, and foraging in dim-light environments has evolved repeatedly. Facultative dim-light foraging behaviour is known in five of nine families of bees, while obligate behaviour is known in four families and evolved independently at least 19 times. The light intensity under which bees fo...