OBJECTIVE This study aimed to show the effects of intra-operative diltiazem infusion on flow in arterial and venous grafts in coronary artery bypass graft surgery. METHODS Hundred fourty patients with a total of 361 grafts [205 (57%) arterial and 156 (43%) venous] underwent isolated coronary surgery. All the grafts were measured by intraoperative transit time flow meter intra-operatively. Gro...

Effects of Ca2+ antagonists, verapamil and diltiazem, on uptake and release of Ca2+ by microsomes of the renal cortex were studied. Verapamil inhibited the ATP-dependent Ca2+ uptake by renal microsomes. Addition of 0.8 mM verapamil was required to produce 50% inhibition of the ATP-dependent CA2+ uptake. Diltiazem also depressed the Ca2+ uptake was not due to an increased permeability for Ca2+, ...

This report describes the use of diltiazem to control circulatory fluctuations during anaesthesia in five patients undergoing resection of a phaeochromocytoma. Diltiazem was administered continuously i.v. before anaesthesia and during surgery until the draining vein from the tumour had been ligated. Arterial pressure and systemic vascular resistance decreased in association with the infusion of...

To cite: Toescu SM, Kennon S, Stevens H. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2013201536 DESCRIPTION A 64-year-old man presented with a 12-month history of angina. Following coronary angiography he underwent percutaneous coronary intervention with deployment of drug-eluting stents to the left anterior descending and main diagonal branch. He was discharg...

BACKGROUND Calcium antagonists are a first-line treatment for hypertension. The effectiveness of diltiazem, a non-dihydropyridine calcium antagonist, in reducing cardiovascular morbidity or mortality is unclear. We compared the effects of diltiazem with that of diuretics, beta-blockers, or both on cardiovascular morbidity and mortality in hypertensive patients. METHODS In a prospective, rando...

A new high-performance liquid chromatographic method has been developed for the determination of diltiazem in human cardiac tissue. Tissue samples are homogenized and digested with trypsin solution. Diltiazem and the internal standard are extracted with acetone. The extract is evaporated to dryness and reconstituted in potassium phosphate buffer. Samples are then cleaned up with solid-phase ext...

The authors would like to thank Professor Halil Dogan (Bakirkoy Dr. Sadi Konuk Training and Research Hospital, Istanbul, Turkey) for informing them of the following error. The following sentence within the last paragraph of the ‘Diltiazem and Atrial Arrhythmias’ section, ‘‘A retrospective study evaluated 77 patients with supraventricular tachycardia treated with oral adenosine or intravenous di...

The goal of this study was to determine the effects of the L-type calcium channel blockers verapamil and diltiazem on the currents of voltage-gated potassium channel (fKv1.4ΔN), an N-terminal-deleted mutant of the ferret Kv1.4 potassium channel. Measurements were made using a two electrode voltage clamp technique with channels expressed stably in Xenopus oocytes. The fKv1.4ΔN currents displayed...

INTRODUCTION Calcium channel blockers have an excellent effectiveness in the conservative management of chronic anal fissure (CAF). OBJECTIVES To assess the long-term results of management with diltiazem 2% ointment using a telephone questionnaire. METHODS A descriptive, retrospective study from March 2004 to March 2011 in patients with CAF on diltiazem 2%, 3 applications daily for 4-6 week...

Currently, there is still a lack of an optimal treatment for no reflow phenomenon (NRP). We analyzed the efficacy and safety of using nondihydropyridine calcium channel antagonists (NDHP, verapamil/diltiazem) in patients suffering from NRP. Eight RCTs with 494 participants were eligible for analysis. The pooling analysis showed that intracoronary verapamil/diltiazem injection significantly decr...