A 73-year-old woman visited our hospital complaining of general fatigue and jaundice. Laboratory tests revealed an elevated total bilirubin, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and γ-glutamyltransferase. Computed tomography and magnetic resonance imaging demonstrated a mass lesion at the ampulla of Vater with dilatation of the common bile duct and main pan...

Sinonasal tract malignancies are uncommon, representing no more than 5% of all head and neck neoplasms. However, in contrast to other head and neck sites, a significant proportion of sinonasal neoplasms tend to display a poorly/ undifferentiated significantly overlapping morphology and a highly aggressive clinical course, despite being of diverse histogenetic and molecular pathogenesis. The wid...

In this paper, we describe the case of successful surgical treatment a rare combination three malignant tumors major duodenal papilla in one patient. A 59-year-old woman presented with abdominal pain, fever, nausea, vomiting, weight loss and obstructive jaundice. After routine examination, patient suspected cancer underwent pylorus-sparing pancreatoduodenal resection. Final histology revealed c...

Pancreatic poorly differentiated neuroendocrine tumors (PDNETs) are a subtype of neuroendocrine tumors (NETs) that are clinically distinguished by their very rapid growth. They are immunohistochemically diagnosed by having a higher Ki-67 cancer cell staining percentage when compared with well or intermediately differentiated NETs. These tumors are typically treated in the same manner as small c...

This is a retrospective analysis of poorly-differentiated head and neck malignancies at University College Hospital, Ibadan. Eighty-six poorly-differentiated neoplasms were categorized as carcinomas, sarcomas, lymphomas or neuroendocrine cancers with a panel of 7 antibodies (cytokeratin AE1/AE3, vimentin, desmin, myogenin, leukocyte common antigen and neuron-specific enolase). Immunohistochemic...

Background and Aim: Neuroendocrine tumors of liver are rare, arising predominantly from neuroendocrine cells liver. PHNETs mimics Hepatocellular Carcinoma Cholangiocarcinoma frequently. It is common for HCC to present in the portal delayed phases with prominent arterial enhancement washout, potentially confounding diagnosis PHNET. Case Report: 68/M, diabetic, hypertensive & COAD on regular trea...

Neuroendocrine tumours constitute a group of tumours that originate from neuroendocrine cells throughout the body. That includes endocrine tumours of the thymus, lung, pancreas and gastrointestinal tract. Neuroendocrine gastrointestinal tumours have classically been divided into carcinoid tumours and endocrine pancreatic tumours. Many of these tumours produce hormones that can induce clinical s...

  Radioiodine (1-131) is the treatment of choice in differentiated thyroid carcinoma. External radiotlierapy however, has it's own roie in these tumors. Treatment of anaplastic thyroid carcinoma 1ms not acliieved any notahle success yet, though combined - modality regimens of radiotherapy and chemotherapy have sometimes shown significant results. In this paper the rol...

Large cell neuroendocrine tumor of the urinary bladder is very rare. It is a type of neuroendocrine carcinoma that is morphologically different from small cell carcinoma. This manuscript describes a 67-year-old man who presented with hematuria. Ultrasonogrophic and computer tomography revealed a 5 cm mass in right posterolateral wall of the bladder that invaded perivesical tissue and he subsequ...