The aim of this study was to examine whether bovine colostrum was able to prevent the NSAID induced small intestinal damage in animals. The animal model population of the study consisted of 4 groups: control group, diclofenac group, diclofenac with 10% low fat milk group and diclofenac with 5% colostrum group. The animals with milk or colostrum were fed with 10% low fat milk or 5% colostral sol...

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). A efficient, simple and least time consuming spectrophotometric method for the assay of diclofenac sodium has been developed. Comparison of assay of four different brands of diclofenac sodium (Dicloran, Defnac, Artifin, voltral) has also been done available in public medical store of Karachi, Pakistan. The assay is based on the ultrav...

The efficacy and safety of Nimulid (Nimesulide) and Diclofenac was evaluated in a double blind randomized diclofenac controlled trial in patients suffering from osteoarthritis of the knee joint. Out of 141 patients, 71 (42 mates, 29female) received Nimulid 100 mg. BD and 70 patients (40 male, 30 female) received Diclofenac 75 mg BD. There was no statistically significant difference in the age, ...

The present study was performed to investigate the effects of long-term intraperitoneal (IP) injection of vitamin B12 and diclofenac in separate and combined treatments on cold and mechanical allodynia in a neuropathic pain model in rats. Neuropathic pain was induced by crush injury in right tibial nerve. Acetone spray and von Frey tests were used to obtain cold and mechanical allodynia respons...

OBJECTIVE Postpericardiotomy syndrome (PPS), which is thought to be related to autoimmune phenomena, represents a common postoperative complication in cardiac surgery. Late pericardial effusions after cardiac surgery are usually related to PPS and can progress to cardiac tamponade. Preventive measures can reduce postoperative morbidity and mortality related to PPS. In a previous study, diclofen...

The metabolism of diclofenac to its 5-hydroxylated derivative in humans is catalyzed by cytochrome P450 (CYP)3A4. We report herein that in vitro this biotransformation pathway is stimulated by quinidine. When diclofenac was incubated with human liver microsomes in the presence of quinidine, the formation of 5-hydroxydiclofenac increased approximately 6-fold relative to controls. Similar phenome...

A simple high-performance liquid chromatography (HPLC) method has been developed for determination of diclofenac in human plasma. The method was validated on Ace C(18) column using UV detection. The mobile phase consisted of 20 mM phosphate buffer (pH 7) containing 0.1% trifluoroacetic acid-acetonitrile (65:35, v/v). Calibration curve was linear between the concentration range of 75-4000 ng/mL....

The objectives of present investigation were to achieve immediate release of paracetamol and tailored release of diclofenac sodium from bi-layer tablets. A 2(3) full factorial design was adopted using the amount of polyethylene glycol, microcrystalline cellulose and crospovidone as independent variables for fabricating paracetamol tablets. Diclofenac sodium tablets were prepared using hydroxypr...

Tabrizi et al., 1996 synthesizes polymeric prodrugs of the diclofenac by attaching Diclofenac to poychloromethylstyrene, polyvinyl chloroacetate and polyethylene glycol through the hydrolyzable ester bonds, and assessed in vitro for usefulness as diclofenac prodrugs. These polymers were obsereved potentially useful as polymeric prodrugs but polyvinyl chloroacetate was found an appropriate carri...

BACKGROUND The aim of the present work was to characterize the electrophysiological effects of the non-steroidal anti-inflammatory drug diclofenac and to study the possible proarrhythmic potency of the drug in ventricular muscle. METHODS Ion currents were recorded using voltage clamp technique in canine single ventricular cells and action potentials were obtained from canine ventricular prepa...