نتایج جستجو برای: dicentric chromosomes
تعداد نتایج: 69244 فیلتر نتایج به سال:
A woman with first trimester abortion and a dicentric chromosome formed from a 4 and a 21 is described. The dicentric chromosome was stable and in the majority of cells the 21 centromere was active, while in a minority the chromosome 4 centromere was active. This shows that both centromeres were functional, but that only one functioned in any given cell. Suppression of the activity of one centr...
The genotoxic activity of microcystin-LR (MC-LR) is a matter of debate. MC-LR is known to be a phosphatase inhibitor and it may be expected that it is involved in the regulation of the activity of DNA-dependent protein kinase (DNA-PK), the key enzyme involved in the repair of radiation-induced DNA damage. We studied the effect of MC-LR on the repair capacity of radiation-induced DNA damage in h...
BACKGROUND To evaluate the clinical association of extrastructurally abnormal chromosomes (ESACs) with pregnancy outcome based on the cytogenetic characteristics of the ESACs. METHODS We retrospectively reviewed 12 ESAC cases identified from 12,991 cases who received genetic amniocentesis between January 1983 and March 2008. Prenatal ultrasound findings, characteristics of ESACs (karyotypes, ...
Radiomimetic compounds, similarly to ionising radiation can directly or indirectly cause DNA damage. Two major groups of these alkylating agents and antimetabolites, have already been discussed in the first part this article. The topic article is an overview radiomimetic substances biological origin; they are grouped upon their chemical structure. Some bacteria, belonging class Actinobacteria p...
Diagnostic and therapeutic radiation fields are planned so as to reduce side-effects while maximising the dose to site but effects on healthy tissues are inevitable. Radiation causes strand breaks in DNA of exposed cells which can lead to chromosomal aberrations and cause malfunction and cell death. Several researchers have highlighted the damaging effects of high dose radiation but still there...
For three species of grasshoppers the volumes of the largest and the smallest metaphase chromosome differ by a factor of 10, but the microtubules (MTs) attached to the individual kinetochores show no corresponding range in numbers. Locusta mitotic metaphase chromosomes range from 2 to 21 mum, and the average number of MTs per kinetochore is 21 with an SD of 4.6. Locusta meiotic bivalents at lat...
The frequency of sister chromatid exchanges (SCE), structural chromosomal aberrations and the number of chromosomes in the peripheral blood lymphocytes from stainless steel welders were studied. The surveys were carried out three times during a period of three years. There were no significant differences in the mean value and variance of SCE frequency among these three surveys both in the welde...
We present a prototype software system with sufficient capacity and speed to estimate radiation exposures in a mass casualty event by counting dicentric chromosomes (DCs) in metaphase cells from many individuals. Top-ranked metaphase cell images are segmented by classifying and defining chromosomes with an active contour gradient vector field (GVF) and by determining centromere locations along ...
PURPOSE Two quality controlled inter-laboratory exercises were organized within the EU project 'Realizing the European Network of Biodosimetry (RENEB)' to further optimize the dicentric chromosome assay (DCA) and to identify needs for training and harmonization activities within the RENEB network. MATERIALS AND METHODS The general study design included blood shipment, sample processing, analy...
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