AIM To investigate the efficacy of thrombomodulin (TM)-α for treatment of disseminated intravascular coagulopathy (DIC) in the field of gastrointestinal surgery. METHODS Thirty-six peri-operative DIC patients in the field of gastrointestinal surgery who were treated with TM-α were retrospectively investigated. The relationships between patient demographics and the efficacy of TM-α were examin...

Adrenomedullin (ADM) is a regulatory peptide having a variety of pharmacological properties secreted from vascular endothelial cells and adrenal medulla. There are only a few studies about the effects of ADM on coagulation and platelets which is secreted from endothelial cells. The aim of this study is to assay ADM levels in rabbits with endotoxin induced disseminated intravascular coagulation ...

The diagnosis of disseminated intravascular coagulation (DIC) should encompass both clinical and laboratory information. The International Society for Thrombosis and Haemostasis (ISTH) DIC scoring system provides objective measurement of DIC. Where DIC is present the scoring system correlates with key clinical observations and outcomes. It is important to repeat the tests to monitor the dynamic...

BACKGROUND Neutrophil elastase, alveolar thrombin generation, and fibrin deposition play crucial roles in the development of acute respiratory distress syndrome (ARDS) and disseminated intravascular coagulation (DIC). However, the usefulness of combination therapy with a selective neutrophil elastase inhibitor, sivelestat, and recombinant human soluble thrombomodulin (rhTM) for patients with AR...

Disseminated intravascular coagulopathy (DIC) is an acquired disease that occurs secondary to a variety of underlying conditions including solid tumors. Prostate cancer (PCa) is one of these tumors and DIC is the most prevalent coagulopathy related to PCa, but it is rarely reported as the first manifestation of it. This paper is a report of an 85-year-old man who presented with hematuria and va...

• ORA vs. B>1 indicates a higher response rate in favour of treatment A. • The DIC (Deviance Information Criterion) is commonly used to select fixed vs. random effects model • DIC represents a trade-off between model adequacy and complexity (i.e. complex models, for example a random effect vs a fixed effect model, are penalised) • The model associated with the lowest DIC is selected, considerin...

Disseminated intravascular coagulation (DIC) is the physiologic result of pathologic overstimulation of the coagulation system. Despite multiple triggers, a myriad of laboratory abnormalities, and a clinical presentation ranging from gross hemostatic failure to life-threatening thrombosis, or even both simultaneously, a simplified clinical approach augmented by a few readily available tests all...

Raman tweezers and quantitative differential interference contrast (DIC) microscopy are combined to monitor the dynamic germination of individual bacterial spores of Bacillus species, as well as the heterogeneity in this process. The DIC bias phase is set properly such that the brightness of DIC images of individual spores is proportional to the dipicolinic acid (DPA) level of the spores, and a...

OBJECTIVES To retrospectively validate the new Chinese DIC scoring system (CDSS). METHODS This study retrospectively collected the information of 619 patients (371 cases with non-hematologic malignancies, 248 cases with hematologic malignancies) who suspected of DIC in Wuhan Union Hospital during 2013-4 to 2014-6. We validated CDSS by comparing it with three leading scoring systems, from Inte...