Complexes of Gd, Eu and Yb(III) have been prepared with a series of heptadentate ligands related to the parent complex AAZTA, based on the 6-methyl-6-aminoperhydrodiazepine moiety. For (RR) and (RS)-diastereoisomers of a di-glutarate ligand, solution NMR studies revealed the presence of two major species that undergo water exchange rates at Gd differing by a factor of six. Comparison of solutio...

Reaction of (+ )-catechin at pH 12 and 40 DC results in the stereoselective (if not stereospecific) formation of an enolic form of 1-[6-(3',4'-dihydroxyphenyl)7 -hydroxybicyclo[3.3.1 Jnonane-2,4,9-trione-3-ylJ -1-(3,4-dihyroxyphenyl )-3-(2,4,6-trihydroxyphenyl)-propan-2-ol. The n.m.r. chemical shift assignments determined by a variety of two-dimensional experiments permit a conclusion that the ...

Density Functional Theory (DFT) in conjuction with the Intrinsic Distortion Path (IDP) is employed to study the Jahn-Teller (JT) effect in all four diastereoisomers of tris(ethylenediamine)copper(II) ([Cu(en)3] ) and tris(ethyleneglycol)copper(II) ([Cu(eg)3] ) complexes. As a consequence of the JT effect all the isomers tetragonally elongate to the C2 configurations. Although there are energy d...

Methods for the separation of photosensitizer isomers, such as benzoporphyrin derivative monoacid, benzoporphyrin ethyl monoacid, 2-[1-hexyloxyethyl]-2-devinylpyropheophorbide-a, diethyleneglycol diester benzoporphyrin derivative, tin ethyl etiopurpurin, and phthalocyanine tetrasulfonate, have been systematically developed by CE. Detection was accomplished by UV absorption at 214 nm or by LIF w...

A regioselective high yielding monochloro substitution (chlorohydrin formation) via Mitsunobu reaction is reported. In carbohydrates and sterically hindered non-sugars, only the primary hydroxyl group is chlorinated, whereas in the non-sugar 1,2- and 1,3-alcohols, predominantly the secondary chloride substitution occurs. The versatile methodology provides indirect access to epoxides with the re...

Starting from (R)-Ugi's amine, diastereoselective lithiation followed by Ar'PCl2 and then Ar’’MgBr led to the generation, as single diastereoisomers, of (R,Sp,Sphos) [Ar’=Ph, Ar’’=o-Tol] (R,Sp,Rphos) [Ar’=o-Tol, Ar’’=Ph] PPFA ligand derivatives. Amine substitution both with HPCy2 gave P-stereogenic Josiphos ligands, addition CuCl, corresponding copper(I) complexes. The latter were also generate...