BACKGROUND Short-term diabetes causes sensory disorders in rats ranging from thermal hypoalgesia to exaggerated behavioral responses to other sensory stimuli. As impaired neurotrophic support may promote sensory nerve disorders during diabetes, the authors investigated whether TX14(A), a neurotrophic peptide derived from prosaposin, was able to ameliorate nerve disorders in diabetic rats. MET...

Efficacy Intra-articular corticosteroid injection is quick and simple to carry out and in RCTs it has a large effect size (ES) of 1.27 at 7 days postinjection for pain relief against placebo for knee OA [101]. It produces relatively rapid relief of severe pain within a few hours or days. Although this benefit is relatively short lasting, in RCTs (1–4 weeks), individual patients may derive benef...

purpose: to evaluate the effect of intravitreal bevacizumab (ivb) injection on sustained intraocular pressure (iop) methods: this non-randomized prospective study was conducted on 359 eyes of 359 patients in amir almomenin (rasht) and labbafinejad (tehran) hospitals. after history taking and complete ocular examination, iop was measured one week and one day before injection (twice at each sessi...

purpose: to evaluate the effects of posterior subtenon triamcinolone acetonide (ta) injection on clinical, angiographic, and optical coherence tomographic (oct) features in refractory diabetic macular edema (dme). method: in a randomized double-masked placebo-controlled clinical trial, 38 consecutive patients (64 eyes) with dme refractory to previous laser therapy or not suitable for such treat...

INTRODUCTION Trigger fingers have been reported in the literature for over a century; yet, the lack of trials comparing open surgery to corticosteroid injection is pronounced. At the initiation of the present study in 2010, no randomized controlled trials could be found comparing open surgery to corticosteroid injection. In the present randomized controlled trial, we plan to compare the efficac...

We present a unique prospective study to estimate the median sustained stage-related improvement in pain and hand function in patients with trapezio-metacarpal joint osteoarthritis after administration of a single corticosteroid injection. Response to the corticosteroid injection was assessed using Disability of Arm Shoulder and Hand (DASH) and Visual Analogue Scale (VAS) pain scores. Self asse...

Bone Joint J 2016;98-B:194–200. Received 29 May 2015; Accepted after revision 8 October 2015 There is conflicting evidence about the benefit of using corticosteroid in periarticular injections for pain relief after total knee arthroplasty (TKA). We carried out a double-blinded, randomised controlled trial to assess the efficacy of using corticosteroid in a periarticular injection to control pai...

Osteoarthritis of the hip is a significant source of morbidity in the elderly. Treatment guidelines are available for the management of hip osteoarthritis, but these do not address the application of intraarticular corticosteroid injection. The intraarticular injection of corticosteroid is used in the management of other large joint osteoarthritic diseases and is well studied in the knee, howev...

Objective: In diabetic patients, hyperglycemia is associated with impaired FOXO signaling pathways in liver cells. This study aimed to determine the effect of resistance training on FOXO1 expression in liver hepatocytes and fasting glucose levels in type 2 diabetic rats. Materials and Methods: In this experimental study, type 2 diabetes induced by intraperitoneal injection of nicotinamide-STZ ...