Evidence for the important role of the potent oxidant peroxynitrite in peripheral diabetic neuropathy and neuropathic pain is emerging. This study evaluated the contribution of neuronal nitric oxide synthase (nNOS) to diabetes-induced nitrosative stress in peripheral nerve and dorsal root ganglia, and peripheral nerve dysfunction and degeneration. Control and nNOS-/- mice were made diabetic wit...

PURPOSE The aim of the study was to investigate the prevalence of peripheral diabetic neuropathy (PDN) and associated characteristics among type 2 diabetic mellitus (DM2) patients in Passo Fundo, a city on Southern Brazil. BASIC PROCEDURES A cross-sectional study was conducted with 340 patients with type 2 diabetes mellitus. Tests were performed to evaluate vibration (tuning fork), light touc...

Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood sugar levels, and the increase in levels triggered low insulin production or ineffective use of body (relatively). Diabetic neuropathy complication that often attacks DM patients highest diabetes. This study aims to test effectiveness Andaliman fruit (Zanthoxylum acanthopodium) extract on improved ...

1. Pulse-wave velocity in both upper and lower limbs has been measured in a series of diabetic and control subjects. Subjects were studied with a Doppler ultrasound system and a real-time frequency analyser. 2. The subjects comprised three groups: (a) diabetic subjects with peripheral neuropathy (43); (b) non-complicated diabetic subjects (8); (c) non-diabetic control subjects (11). Those diabe...

Diabetes is now considered one of the main threats to human health in the 21st century and many researchers are dedicated to investigate the physiopathology of the disease, with further insights on the managements of its major complications. Since understanding the pathophysiology of the major complications of diabetes and their underlying processes is mandatory, experimental models of the dise...

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Endoplasmic reticulum stress resulting from abnormal folding of newly synthesized proteins impairs metabolism, transcriptional regulation, and gene expression, and it is a key mechanism of cell injury. Endoplasmic reticulum stress plays an important role in cardiovascular and neurodegenerative diseases, cancer, and diabetes. We evaluated the role for this phenomenon in diabetic peripheral neuro...

Oxidative stress-induced mitochondrial dysfunction and mitochondrial DNA (mtDNA) damage in peripheral neurons is considered to be important in the development of diabetic neuropathy. Mitochondrial transcription factor A (TFAM) wraps mtDNA and promotes mtDNA replication and transcription. We studied whether overexpression of TFAM reverses experimental peripheral diabetic neuropathy using TFAM tr...

Abstract Background Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Poor adherence to medication common in neuropathy mainly due side effects and poor tolerance medication. Botulinum toxin A intradermal injection has proved efficacy cases of neuropathy, however there a need compare its effect other lines treatment. The aim the study was type versus conventional oral...

Neuropathic pain is an important problem because of its complex natural history, multiple possible etiologies, and poor response to standard physical therapy modalities. Disorders of the peripheral nerve system (PNS) are heterogeneous and may involve motor fibers, sensory fibers, small myelinated and unmyelinated fibers and autonomic nerve fibers, with variable anatomical distribution (single n...