Numerous studies have demonstrated that the reninangiotensin-aldosterone system (RAAS) plays an important role in the progression of chronic kidney disease (CKD). Angiotensin (Ang) II generates intrarenal haemodynamic and inflammatory changes that promote proteinuria, growth of glomerular and tubular cells, inhibition of NO synthesis, stimulation of extracellular matrix synthesis and induction ...

BACKGROUND Dyslipidemia frequently complicates chronic nephropathies and increases the risk of renal and cardiovascular events. This might be ameliorated by drugs, such as angiotensin-converting enzyme inhibitors, which effectively reduce proteinuria. METHODS AND RESULTS In this longitudinal study, we evaluated the extent to which uptitration of the ACE inhibitor lisinopril to maximum tolerat...

OBJECTIVE To assess whether the insulin analog lispro may antagonize the renal effects of IGF-1, a mediator of glomerular hyperfiltration involved in the progression of diabetic and nondiabetic chronic nephropathies. RESEARCH DESIGN AND METHODS In a randomized crossover study, we compared the renal and metabolic responses to regular or lispro insulin (0.1 units/kg body wt) administered after ...

BACKGROUND Data regarding the epidemiology of end-stage renal disease (ESRD) and dialysis in sub-Saharan Africa are scarce and knowledge about the spectrum renal disease is very limited. This study is on the profile of patients with ESRD in a referral hospital in Cameroon. METHODS Medical records of patients with ESRD covering a 10-year period of activities of the Douala General Hospital were...

Nephropathies and especially nephrotoxicity have become one of the serious causes life-threatening conditions because intensive exposure to xenobiotic whether by environmental pollution or drug abuse. The present study was undertaken assess protective effects Cinnamomum zeylanicum stem bark aqueous extract (AECZ) on gentamicin-induced nephrotoxicity. AECZ prepared maceration in water tested ora...

diabetic retinopathy is the leading cause of blindness in the world. strict control of blood sugar, blood pressure, laser therapy, pharmacotherapy and vitrectomy are of among common diabetic retinopathy treatments. further studies to investigate the effect of protein kinase c inhibitors, angiotensin converting enzyme inhibitors, growth hormone and other proposed treatments for diabetic retinopa...