Prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) are the markers of human prostatic gland. However, it is still not completely understood if and how, steroid hormones and growth factors affect their expression and metabolism in the respect to the major pathologies of the gland. Appropriate studies were carried out on histopathologically diagnosed benign prostatic hyperplasia...

Specific dihydrotestosterone (DHT) binding was demonstrated in the whole cell sonicates obtained from serially subcultured human endometrial fibroblasts. This binding showed a high affinity and specificity for DHT (Kd=3.3 X 10(-10) M). Various kinds of excess nonradioactive steroids were arranged, as a result of competition among them, in the following decreasing order of binding affinity: DHT,...

BACKGROUND Previous findings indicate that testosterone level is negatively correlated with the incidence and mortality of cardiovascular diseases in men. Endothelial progenitor cells (EPCs) play a critical role in endothelial healing and vascular integrity. This study aimed to examine the effects of dihydrotestosterone (DHT), an active metabolite of testosterone, on human EPC function and inve...

OBJECTIVES Women have longer rate-corrected QT intervals (QTc) and are at higher risk for developing life-threatening torsades de pointes ventricular arrhythmias than men, especially after taking medications that block cardiac human ether-a-go-go-related gene (HERG)-encoded K(+) channels. The purpose of the present study was to determine if the male sex steroid hormone, dihydrotestosterone (DHT...

The DHT Mainline is a significant extension to the BitTorrent protocol. The DHT Mainline has several million users and is the largest DHT network. This thesis uses the DHT Mainline to generate a recommendation system for torrents. A program was written crawling the entirety of the torrent search engine kickass.to gathering metadata about torrents. The DHT Mainline was then crawled to search for...

In this paper, we present a model for a cluster oriented Distributed Hash Table (DHT). It introduces software nodes, virtual nodes and partitions as high level entities that, in conjunction with the definition of a certain number of invariants, provide for the balancement of a DHT across a set of heterogeneous cluster nodes. The model has the following major features: a) the share of the hash t...

In the P2P network, how to quickly and accurately positioning of resources is a key measure of the performance. Nowadays, distributed P2P system generally adopts DHT search method, DHT-based P2P network search algorithm of P2P is a hot topic. The paper introduces the background and current research status of the DHT. Then focused on the Pastry algorithm, Finally Pastry algorithm was analyzed an...

Abstract Triple negative breast cancer (TNBC) has poor prognosis and neither established biomarkers nor therapeutic targets. On the one hand androgen receptor (AR), a steroid hormone (SR) which is expressed in 10-53% of TNBC proved to be critical for BC proliferation, been proposed as new target TNBC. other hand, we others have shown that membrane ErbB-2 migrates nucleus (nuclear ErbB-2, NErbB-...

Katsevich formula is currently a hot topic for cone-beam computed tomography (CBCT). The filter in the formula can be computed by a regular discrete Hilbert transform (DHT). A configurable single precision floating-point (SPFP) DHT processor is proposed for accelerating the calculation of filter in Katsevich formula. The configurable processor is of memory based architecture with one pipelined ...

Circulating dehydroepiandrosterone (DHEA) is converted to testosterone or estrogen in the target tissues. Recently, we demonstrated that skeletal muscles are capable of locally synthesizing circulating DHEA to testosterone and estrogen. Furthermore, testosterone is converted to 5alpha-dihydrotestosterone (DHT) by 5alpha-reductase and exerts biophysiological actions through binding to androgen r...