An ion source based on the principles of electrostatic field desorption is being developed to improve the performance of existing compact neutron generators. The ion source is an array of gated metal tips derived from field electron emitter array microfabrication technology. A comprehensive summary of development and experimental activities is presented. Many structural modifications to the arr...

Increased calcium uptake in vascular tissue, leading to elevated cytosolic free calcium, has been implicated in the pathophysiology of hypertension. This study examined the dose-dependent effect of deuterium oxide (5%, 10%, or 20% in drinking water) on systolic blood pressure, aortic calcium uptake, and platelet cytosolic free calcium in spontaneously hypertensive rats. Starting at age 8 weeks,...

The study of chemical transformations in the living cell with the aid of the isotope technique requires the preparation of deuterio compounds which contain deuterium atoms linked to carbon atoms. The carbon-deuterium linkages must be stable in the sense that the deuterium atoms will not be replaced by hydrogen atoms on solution in water. In the case of simple organic compounds, standard synthet...

The deuterium-to-hydrogen (D/H or 2H/1H) ratio of Martian atmospheric water (∼6× standard mean ocean water, SMOW) is higher than that known sources, requiring planetary enrichment. A recent measurement by NASA's Mars Science Laboratory rover Curiosity Hesperian-era (>3 Ga) clays yields a D/H ∼3×SMOW, demonstrating most the enrichment occurs early in Mars's history, reinforcing conclusions meteo...

This paper discusses the parameters which influence the operation of hollow cathode and deuterium lamps. Examples are given of how parameters can be selected in order to improve the quality of analytical results. Aspects of deuterium lamp operation for background correction are also covered.

sensitivity and, in spite of the raggedness of the trace at this extreme sensitivity, a displacement of the mean of about one centimeter could have been detected. This would be one-two thousandth of the effect measured in Fig. 1 and, since the proton-current used was four times the deuton-current, we may conclude that any effect produced by protons on carbon is less than one-eight thousandth of...

Deuterium labeling techniques are widely utilized as efficient tools to study the absorption, distribution, metabolism, and excretion (ADME) of pharmaceuticals. Moreover, deuterium-labeled drugs expected prolong half-life drug enhance efficacy drugs, close metabolic sites, decrease side effects. Thus, there is a rising demand for practical construction their intermediates under mild conditions....

The stereochemical course of the reaction catalyzed by a copper amine oxidase from Arthrobacter globiformis has been investigated using 2-phenylethylamine stereospecifically deuterium-labeled at the C1 position. Measurements of deuterium content in the product, phenylacetaldehyde, by gas chromatography-mass spectrometry revealed stereospecific abstraction of the pro-S hydrogen during the enzyma...