Two simple, rapid, accurate and economical 'UV Spectrophotometry' and 'First Order Derivative' methods have been developed for determination of levofloxacin hemihydrate in bulk and tablets. In (10% v/v) acetonitrile, the lambdamax of the drug was found to be 288 nm. The same spectrum was derivatised into first order derivative, using UV probe software of instrument (Shimadzu-2450), at Deltalamb...

A derivative spectrophotometric method was developed to determine NO3(-)-N in plant tissues. The method is based on measurement of the first-derivative spectrum of nitrosalicylic acid in basic solution. The nitrosalicylic acid was obtained by reaction of samples with salicylic acid in concentrated sulfuric acid and was used by Cataldo et al. in nonderivative spectrophotometry. The main strength...

Diphenylcarbazone has been used for the simultaneous and individual determination of zinc(II) and cadmium(II) at trace levels. The carbazone complexes of zinc(II) and cadmium(II) at pH 7–10 are pink in color, and are soluble in TX-100 micellar media. Under optimum conditions, calibration graphs for individual and simultaneous determination by first, second, third and fourth derivative spectroph...

In the present work, five different spectrophotometric techniques for simultaneous determination of formulations containing atorvastatin calcium (ATOR) and fenofibrate (FENO) in various combinations are described. In ratio spectra derivative spectrophotometry, analytical signals were measured at wavelengths corresponding to either maximums or minimums for both drugs in first derivative spectra ...

A rapid, linear (over a concentration range of 0.00012-0.0012% and with correlation coefficient r = 0.999), accurate (an average recovery of 100%), precise (an average standard deviation < 1.5%) and economical first derivative UV spectrophotometric assay method (lambda(max) = 238 nm) was developed for the determination of moexipril hydrochloride (MOXL) in a pharmaceutical formulation. The metho...

Strontium ranelate is used for treatment of osteoporosis. The present work deals with method development for estimation of Strontium ranelate in bulk dosage form by UV spectrophotometry. A new simple, accurate and sensitive method for estimation of Strontium ranelate from bulk dosage form has been developed. The method employs zero order derivative spectroscopy. Estimation of Strontium ranelate...

Objective: Four different methods were used for stability indicating determination of aripiprazole in presence of its oxidation product in pure and its dosage form. Methods: The described methods are namely, second derivative spectrophotometry, first-derivative of ratio spectra; bivariate and thin layer chromatography. Results: The derivative spectrophotometric method was based on measuring the...

The aim of the present work was to develop a simple and rapid method for determination of theophylline (THP) and guaifenesin (GU) in syrup without involving any preparation operations like separation or masking. A HPLC and two spectrophotometric methods based on the derivation of the main spectra are described for the determination of THP and GU in combined pharmaceutical syrup form. The first ...

Two sensitive spectrophotometric methods are presented for the assay of Repaglinide in bulkdrug and in formulations using methyl orange, as reagents. Oxidant by reacting with a fixedamount of either methyl orange and measuring the absorbance at 485.2 nm (method-I) andmeasuring the absorbance at 618.9 nm (method-II). Developed method is based on the formationof extractable colored complex of dru...