نتایج جستجو برای: depleted fetal

تعداد نتایج: 111458  

Journal: :Blood 2001
F Ma M Wada H Yoshino Y Ebihara T Ishii A Manabe R Tanaka T Maekawa M Ito H Mugishima S Asano T Nakahata K Tsuji

In this study, cord blood CD34(+) cells expressed CD81, a member of the transmembrane 4 superfamily, and were classified into 3 subpopulations on the basis of their expression levels: CD34(+)CD81(+), CD34(low)CD81(+), and CD34(+)CD81(high). The lymphohematopoietic activity of each subpopulation was then examined by using suspension and clonogenic cultures for hematopoietic potential, coculture ...

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Journal: :The Biochemical journal 2009
Anne Uimari Tuomo A Keinänen Anne Karppinen Patrick Woster Pekka Uimari Juhani Jänne Leena Alhonen

SSAT (Spermidine/spermine N1-acetyltransferase, also known as SAT1), the key enzyme in the catabolism of polyamines, is turned over rapidly and there is only a low amount present in the cell. In the present study, the regulation of SSAT by spermine analogues, the inducers of the enzyme, was studied in wild-type mouse fetal fibroblasts, expressing endogenous SSAT, and in the SSAT-deficient mouse...

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Journal: :The Journal of clinical investigation 2015
Morgan Jones Jennifer Chase Michelle Brinkmeier Jing Xu Daniel N Weinberg Julien Schira Ann Friedman Sami Malek Jolanta Grembecka Tomasz Cierpicki Yali Dou Sally A Camper Ivan Maillard

Rapidly cycling fetal and neonatal hematopoietic stem cells (HSCs) generate a pool of quiescent adult HSCs after establishing hematopoiesis in the bone marrow. We report an essential role for the trithorax group gene absent, small, or homeotic 1-like (Ash1l) at this developmental transition. Emergence and expansion of Ash1l-deficient fetal/neonatal HSCs were preserved; however, in young adult a...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Kristy M Bialas Takayuki Tanaka Dollnovan Tran Valerie Varner Eduardo Cisneros De La Rosa Flavia Chiuppesi Felix Wussow Lisa Kattenhorn Sheila Macri Erika L Kunz Judy A Estroff Jennifer Kirchherr Yujuan Yue Qihua Fan Michael Lauck David H O'Connor Allison H S Hall Alvarez Xavier Don J Diamond Peter A Barry Amitinder Kaur Sallie R Permar

Elucidation of maternal immune correlates of protection against congenital cytomegalovirus (CMV) is necessary to inform future vaccine design. Here, we present a novel rhesus macaque model of placental rhesus CMV (rhCMV) transmission and use it to dissect determinants of protection against congenital transmission following primary maternal rhCMV infection. In this model, asymptomatic intrauteri...

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2016

FULL PRESCRIBING INFORMATION: CONTENTS* WARNING: FETAL TOXICITY 1 INDICATIONS AND USAGE 1.1 Hypertension 1.2 Hypertensive Patients with Left Ventricular Hypertrophy 1.3 Nephropathy in Type 2 Diabetic Patients 2 DOSAGE AND ADMINISTRATION 2.1 Hypertension 2.2 Hypertensive Patients with Left Ventricular Hypertrophy 2.3 Nephropathy in Type 2 Diabetic Patients 2.4 Dosage Modifications in Patients wi...

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Journal: :Energies 2020

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Journal: :International Journal of Environmental Research and Public Health 2010

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Journal: :Military Medicine 2002

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Journal: :Proceedings of the National Academy of Sciences 1988

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Journal: :Blood 1989
M Gabbianelli E Pelosi E Bassano C Labbaye S Petti E Rocca E Tritarelli B A Miller M Valtieri U Testa

Reactivation of fetal hemoglobin (HbF, alpha 2 gamma 2) synthesis was previously reported in normal human adult erythroblast colonies ("bursts") generated by erythroid progenitors (BFU-E) in fetal calf serum-supplemented (FCS+) semisolid cultures stimulated with erythropoietin (Ep). Our studies focused on the reactivation of HbF synthesis in normal adult erythroid bursts generated by peripheral...

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  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->