نتایج جستجو برای: dependent calcium channels
تعداد نتایج: 937104 فیلتر نتایج به سال:
Native T-type voltage-dependent calcium channels are low voltage-activated and have a small single channel conductance of 5-8 pS, which distinguishes them from any known cloned calcium channels whose conductances are 12-25 pS. Here, we show that when alpha1B, alpha1E, or alpha1C are expressed in COS7 cells, which contain no endogenous calcium channel subunits or calcium channels, they each exhi...
Electrical stimulation of isolated adult rat heart cells in suspension at 4 Hz resulted in a fourfold increase in the rate of sodium influx and efflux across the sarcolemma, with no change in total cell sodium, as measured with 22Na. The magnitude of stimulation-dependent sodium fluxes under these conditions averaged 17 nmol/min/mg protein. The increased rate of efflux was inhibited by tetrodot...
Calcium-dependent inactivation of NMDA channels was examined on cultured rat hippocampal neurons using whole-cell voltage-clamp and cell-attached single-channel recording. An ATP regeneration solution was included in the patch pipette to retard current "rundown." In normal [Ca2+]o (1-2 mM) and 10 microM glycine, macroscopic currents evoked by 15 sec applications of NMDA (10 microM) inactivated ...
Voltage-gated calcium channel (Ca(v))2.2 (N-type calcium channels) are key components in nociceptive transmission pathways. Ziconotide, a state-independent peptide inhibitor of Ca(v)2.2 channels, is efficacious in treating refractory pain but exhibits a narrow therapeutic window and must be administered intrathecally. We have discovered an N-triazole oxindole, (3R)-5-(3-chloro-4-fluorophenyl)-3...
T-type calcium channels are important for a variety of physiological processes such as brain and heart function. Proper regulation of these channels by second messengers is fundamental, however, our knowledge of the molecular pathways that regulate T-type calcium channels is limited in comparison with other voltage-dependent calcium channels. In this issue of Molecular Pharmacology, Tao and col...
Calcium enters neurons or nerve terminals through the surface membrane, and then diffuses inwardly and is diluted. Calcium acts at membrane sites to release transmitter or modulate channels, or at organelles or the nucleus to regulate metabolism. Thus the average cytoplasmic calcium concentration is a poor predictor of calcium-dependent processes. Solutions of the diffusion equation with approp...
The nociceptive noxious heat-activated receptor - TRPV1, conducts calcium and sodium, thus producing a depolarizing receptor potential, leading to activation of nociceptive neurons. TRPV1-mediated calcium and sodium influx is negatively modulated by calcium, via calcium-dependent desensitization of TRPV1 channels. A mitochondrial Ca2+ uniporter - MCU, controls mitochondrial Ca2+ entry while a s...
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