Dengue is acute viral disease transmitted to humans by Aedes mosquitoes (Ae. aegypti, Ae. albopictus). Dengue virus belongs to the family Flaviviridae, genus Flavivirus. There are four dengue virus serotypes (1-4) which are maintained endemically. The disease is endemic in tropical and subtropical areas between latitudes 35 degrees N and 35 degrees S. Infections may be asymptomatic or may produ...

Dengue fever is a potentially life-threatening vector-borne tropical disease caused by a single-stranded positive-sense ribonucleic acid virus belonging to the Flaviviridae family. Outbreaks have increased in severity over the past few years, especially in developing countries in South Asia[1]. While dengue fever is a self-limiting illness in the majority of patients, about 0.5% of patients dev...

OBJECTIVES To describe the epidemiology, clinical features and treatment of dengue fever and dengue shock syndrome. SOURCES To prepare this review, a literature search was made on PubMed and on the World Health Organization (WHO) and PAHO websites using the terms dengue and dengue shock syndrome. This information was complemented with personal practice. SUMMARY OF THE FINDINGS Dengue is the...

Dengue virus, the causative agent of dengue fever (DF) and more severe forms of the disease – dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) – can infect a number of different types of cells. While monocytes and macrophages are considered to be primary target cells driving the pathology of the disease, numerous studies have implicated the liver as a site of dengue virus replica...

Considerable attention has recently been drawn at the global level to the serious threat to humans caused by new, emerging and re-emerging infectious diseases. Among the infectious vector-borne diseases, dengue, dengue haemorrhagic fever, yellow fever, plague, malaria, leishmaniasis, rodent-borne viruses and arboviruses are considered to be persisting, and sometimes re-emerging, with serious th...

Dengue virus (DENV) is a positive-sense, single-stranded RNA virus that is transmitted by Aedes aegypti and Aedes albopictus mosquitoes. Greater than 100 million cases of dengue fever occur annually and over 2 billion people live in areas at risk for dengue transmission. There are four phylogenetically and serologically distinct DENV, which are capable of human-to-mosquito-to-human transmission...

Dengue may be the most widespread arboviral illness worldwide. Most patients with dengue infection have only mild disease or classic dengue fever, with influenza-like symptoms, severe headache, and aching joints and muscles. However, in a small percentage of patients — maybe half a million people every year — potentially lethal forms of dengue called dengue hemorrhagic fever and dengue shock sy...

The clinical and laboratory parameters of dengue in children, along with predictive markers of dengue shock syndrome (DSS), were studied in Mumbai in 2003. In 2004, there was again a resurgence of dengue in Mumbai and a prospective study of children admitted in hospital was undertaken to determine the clinical and laboratory features of dengue, with specific features in order of severity of the...

An outbreak detection and response system, using time series moving percentile method based on historical data, in China has been used for identifying dengue fever outbreaks since 2008. For dengue fever outbreaks reported from 2009 to 2012, this system achieved a sensitivity of 100%, a specificity of 99.8% and a median time to detection of 3 days, which indicated that the system was a useful de...

BACKGROUND Demographic features of dengue fever have changed tremendously in Pakistan over the past two decades. Small scale studies from all over the country have reported different aspects of individual outbreaks during this time. However, there is scarcity of data looking at the overall trend of dengue virus infection in the country. In this study, we examined annual trends, seasonality, and...