introduction: sonophoresis has been assessed as a novel approach to create skin permeability and drug delivery using low frequencies of ultrasound waves in the range of 20 khz to 3 mhz. in this study, a system including seven 40 khz piezoelectric transducers and an insulin chamber designed by the medical physics research center has been evaluated on hyperglycemic rabbits. materials and methods:...

background: progress in the field of biology and biochemistry has led to the discovery of numerous bioactive peptides and proteins in the last few decades. delivery of therapeutic proteins/peptides has received a considerable amount of attention in recent years. methods: in this study, a two-step desolvation method was used to produce biodegradable hydrophilic gelatin nanoparticles (gnp) as a d...

objective: curcumin is extracted from curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (dna) and messengers (rna). a wide range of studies have been conducted on the physicochemical traits and pharmaco...

objective(s): pei based nanoparticle (np) due to dual capabilities of proton sponge and dna binding is known as powerful tool for nucleic acid delivery to cells. however, serious cytotoxicity and complicated conditions, which govern nps properties and its interactions with cells practically, hindered achievement to high transfection efficiency. here, we have tried to optimize the properties of ...

in recent years, encapsulation of drugs and antigens in hydrogels, specifically in calcium alginate particles, is an interesting and practical technique that was developed widespread. it is well known that alginate solution, under proper conditions, can form suitable nanoparticles as a promising carrier system, for vaccine delivery. the aim of this study was to synthesis alginate nanoparticles ...

the delivery of therapeutic proteins has gained momentum with development of biotechnology. however, large molecular weight, hydrophilic nature and susceptibility to harsh environment of gastrointestinal tract (git) resulted in low absorption. the main objective of this work was the design of a particulate system for oral delivery of recombinant human growth hormone (rhgh) on the basis of parti...