The biological characteristics of hypersensitivity reactions of delayed type are, in general, much the same as are those of many tissue responses known to be mediated by antibodies. For example, the requirement for structural specificity on the par t of agents which evoke delayed allergic reactions seems to be just as exacting as is the case for antigens in classical immunological systems (1). ...

T cell-dependent activation of resident tissue mast cells is required for the elicitation of delayed-type hypersensitivity skin reactions in mice. A T cell-derived antigen-binding factor that transfers the ability to elicit an immediate hypersensitivity-like skin reaction is described and compared with a hybridoma IgE antibody. Both the T cell factor and IgE mediate reactions with increased vas...

background: plant extracts have been widely investigated for possible immunomodu-latory properties. objective: to study the immunomodulatory functions of the metha-nol extract of haussknechtia elymatica (apioideae), an herb native to south-western iran. methods: delayed type hypersensitivity (dth) skin test and measurement of an-tibody titer after immunization with sheep-rbc was performed. [3h]...

The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findi...

‘Drug Induced Hypersensitivity Syndrome’ (DiHS) or Rash with Eosinophilia and Systemic Symptoms’ (DRESS) syndrome is a life threatening, delayed type drug hypersensitivity reaction. This characterized by fever, skin rash, lymphadenopathy, hematological abnormalities visceral involvement liver the most frequently involved organ. Liver mostly presented as acute anicteric hepatitis elevated enzyme...

Small chemicals like drugs tend to bind to proteins via noncovalent bonds, e.g. hydrogen bonds, salt bridges or electrostatic interactions. Some chemicals interact with other molecules than the actual target ligand, representing so-called 'off-target' activities of drugs. Such interactions are a main cause of adverse side effects to drugs and are normally classified as predictable type A reacti...