Dr. Henry Lynch was one of the first to recognize the existence of hereditary nonpolyposis colorectal cancer (HNPCC). While a relatively small percentage of families have this cancer predisposition syndrome, identification of individuals at risk is now standard of care and includes the potential for the prevention of colorectal cancer. Dr. Lynch and Jane Lynch have written a guide highlighting ...

PURPOSE The Arg/Pro polymorphism in codon 72 of p53 was recently associated with age of onset of colorectal cancer in Lynch syndrome. A novel polymorphism in the promoter region of MDM2 was associated with age of cancer onset in Li-Fraumeni syndrome. We studied the influence of both polymorphisms on age of onset in Lynch syndrome and of the p53 polymorphism also in sporadic colorectal cancer. ...

I discuss how the Multiple Pathway Anchoring and Adjustment model is similar to and different from the Feldman and Lynch accessibility-diagnosticity model, elaborated as an anchoring and adjustment model by Lynch, Marmorstein, andWeigold. Cohen and Reed’s concept of representational sufficiency embraces both attitude coherence and retrieval fluency; these map to prior operationalizations of dia...

A survey of adult mosquitoes in the area Palmar dam, Uruguay, was conducted from October 1980 to March 1981, prior filling reservoir. The Culicidae fauna consisted 22 species 7 genera: Aedeomyia Theobald, Aedes Meigen, Anopheles Culex Linnaeus, Mansonia Blanchard, Psorophora Robineau-Desvoidy and Uranotaenia Lynch-Arribálzaga; most diverse genera being (subgenus Ochlerotatus Lynch-Arribálzaga),...

Lynch syndrome is the most common cause of inherited colorectal cancer, totaling 5 to 8% of all the cases with high susceptibility to this type of cancer and extracolonic cancer. It is related to germinal mutations taking place at mismatch repair genes. The diagnosis of Lynch syndrome is essential for both monitoring patients with this disease and detecting asymptomatic carriers, in order to es...

Endometrial cancer arises from the uterine body and fundus in many cases, but can also originate from the lower region of the uterine body through the upper region of the cervix. Such tumors are referred to as carcinoma of the lower uterine segment (LUS) or isthmus, and account for 3-6.3% of all cases of endometrial cancer. This relatively low incidence has permitted performance of only small-s...

Desde hace algunos años, existe la opinión de que generación nacida entre 1981 y 1996, los llamados millennials, muestran apatía por política no están interesados en participar nada relacionado con ella. Sin embargo, cada vez más estudios señalan este grupo joven bien está interesado un tipo diferente. El libro Shauna L. Shames, Out of the Running, profundiza esta cuestión a partir examinar el ...

Colorectal cancer (CRC) due to mismatch repair (MMR) defect has distinct characteristics among unselected CRCs. These CRCs are biologically less aggressive and, thus, showing better prognosis but less sensitive to the 5FU-based chemotherapy. CRCs with MMR defect derive from both hereditary and sporadic reasons. Germline inactivation of MMR genes (hMLH1, hMSH2, hMSH6, and hPMS2) underlies the he...

BACKGROUND There is limited research on why some individuals who have undergone predictive genetic testing for Lynch syndrome do not adhere to screening recommendations. This study aimed to explore qualitatively how Lynch syndrome non-carriers and carriers translate genetic risk information and advice to decisions about risk managment behaviours in the Australian healthcare system. METHODS Pa...

INTRODUCTION Over 125,000 women die of postpartum haemorrhage (PPH) each year, with the commonest cause being uterine atony (75-90 percent). Failing conservative management, hysterectomy is usually the final resort. In 1997, Christopher B-Lynch devised an innovative technique to treat uterine atony, and it has been widely used around the world since its original report. However, there are hardl...