K. P. Murphy et al. (1, 2, 3) recently proposed what would appear to be a profound change in our way of thinking about hydrophobic interactions. On the basis of their elegant and careful experiments on small molecules (4) and on proteins (5), they propose that "for globular proteins hydrophobic interactions lead to destabilization" (1) and that "the hydration effect of nonpolar solutes stabiliz...

PURPOSE The purpose of the present study was to determine the degree of expression of virulence factors such as adherence, cell surface hydrophobicity (CSH) and production of proteinase by different morphological forms of Candida albicans causing oral candidiasis in human immunodeficiency virus (HIV)-infected individuals. METHODS C. albicans 3153A and two strains isolated from oral thrush in ...

Hydrophobicity of a protein is considered to be one of the major intrinsic factors dictating the protein aggregation propensity. Understanding how protein hydrophobicity is determined is, therefore, of central importance in preventing protein aggregation diseases and in the biotechnological production of human therapeutics. Traditionally, protein hydrophobicity is estimated based on hydrophobic...

In the present study we have utilized the structural framework of the analog GS14K4 (cyclo(VKLd-KVd-YPL KVKLd-YP, where d denotes a d-amino acid)), to examine the role of hydrophobicity in microbial activity and specificity. The hydrophobicity of GS14K4 was systematically altered by residue replacements in the hydrophobic sites of the molecule to produce a series of analogs that were either les...

Trace elements have significant effect on the physiology of bacteria. Variation in the concentration of trace elements may affect the expression of virulence by microorganisms. The effect of trace elements on hydrophobicity and adherence of E.coli to uroepithelial cells was studied. Increasing concentrations of Ca2+, Mg2+, Fe3+ and Zn2+ significantly decreased the surface hydrophobicity. Toxic ...

A simple and rapid microextraction procedure based on the application of magnetic nanoparticles and hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) was applied to trace determination of gatifloxacin. A mixture of [Hpy][PF6] and magnetic nanoparticles was injected into the sample solution containing the analyse of interest and a cloudy solution was forme...

A simple and rapid microextraction procedure based on the application of magnetic nanoparticles and hydrophobic 1-Hexylpyridinium hexafluorophosphate [Hpy][PF6] ionic liquid (IL) was applied to trace determination of gatifloxacin. A mixture of [Hpy][PF6] and magnetic nanoparticles was injected into the sample solution containing the analyse of interest and a cloudy solution was forme...

the probability that the commutator of two group elements is equal to a given element has been introduced in literature few years ago. several authors have investigated this notion with methods of the representation theory and with combinatorial techniques. here we illustrate that a wider context may be considered and show some structural restrictions on the group.

In this work it is shown that three pairs of the factors appear to be the key, i.e. main factors of a natural classification of protein amino acids, i.e. canonical amino acids within the amino acid (genetic) code. First pair: the factors of the habit (habitus) of an amino acid molecule (size and polarity). Second pair: the factors of the association (type of the amino acid – enzyme reactivity a...