BACKGROUND The factors associated with lateral curve flexibility in degenerative scoliosis have not been well documented. Disc degeneration could result in significant change in stiffness and range of motion in lateral bending films. The osteophytes could be commonly observed in degenerative spine but the relationship between osteophyte formation and curve flexibility remains controversial. The...

MATERIALS AND METHODS. The study of the preliminary results and retrospective chart review of collected clinical and radiographic outcomes in 12 patients who underwent Direct Lateral Interbody Fusion L1-L5 as a treatment for degenerative disc disease, degenerative scoliosis and/or degenerative spondylolisthesis. Clinical outcomes measured include Visual Analog Scale (VAS) and Radiographic outcome.

Atsttrin, an engineered molecule composed of three fragments of progranulin(PGRN), exerts comparable anti-inflammation ability. Intervertebral disc degeneration (IDD) is involved in inflammation in which TNF-α plays a key role. This study aims to examine the effect and the mechanism of Atsttrin in the pathogenesis of intervertebral disc degeneration. For this purpose, we took advantage of murin...

Herniation of a thoracic disc in an acromegalic giant is reported. Degenerative changes in the spine in association with dorsal kyphosis, and the additional strain, resulted in the disc prolapse.

Degenerative disc disease (DDD) is associated with spinal pain often leading to long-term disability. However, the non-chondrodystrophic canine intervertebral disc is protected from the development of DDD, ostensibly due to its retention of notochordal cells (NC) in the nucleus pulposus (NP). In this study, we hypothesized that secretome analysis of the NC-rich NP will lead to the identificatio...

STUDY DESIGN Clinical adjacent segment pathology (CASP) is common after cervical disc surgery. A critical examination of 320 patients operated for cervical disc prolapse revealed that CASP can also occur in patients with congenital and degenerative fusion of cervical spine. This has not been studied in depth and there is a need for a practically applicable classification of CASP. PURPOSE To d...

INTRODUCTION: The intervertebral disc (IVD) is fibro-cartilaginous structures, composed of two major regions; the outer ring, called annulus fibrosus and the inner part, called the nucleus pulposus. These different tissues including cellular components maintain the metabolism of IVD and play an important role in mechanical function of spine. IVD is well known to degenerate by age, however the c...

There is a growing body of evidence concerning the significant role of silicon in development and composition of both connective and bone tissue. Bio-essential silicon shows strong chemical and biological affinity to aluminum, which is toxic and biologically inessential element. The presence of silicon was confirmed in a variety of tissues; however, it has never been examined in intervertebral ...