The clinical importance of vitamin D has been recently highlighted, due to non-skeletal effects of vitamin D and the fact that vitamin D receptors are observed in many kinds of cells. Vitamin D deficiency or insufficiency results in the development of gastrointestinal diseases, including obesity, hepatitis B, chronic hepatitis C, and inflammatory bowel disease in children. The prevalence of vit...

Thyroid hormones play an important role during pregnancy, providing organogenesis, growth and development of the fetus, teach in formation brain its structure, influencing cognitive abilities. dysfunction is associated with pathological course pregnancy childbirth, as well a negative effect on fetus. Iodine deficiency, which persists throughout Uzbekistan, creates prerequisites for more frequen...

Vitamin B12 deficiency results in neuropsychiatric, hematologic, gynecologic, cardiovascular, and cutaneous manifestations. It is seen most commonly in the elderly, malabsorption diseases  (>60% of all cases), vegans, and vegetarians. Manifestations of pernicious anemia may be similar to Addison disease and may lead to a misdiagnosis. Herein, we report two cases of vitamin B12 deficiency in whi...

BACKGROUND Vitamin D deficiency has been associated with acute stroke and other cardiovascular diseases in the developed world. Low 25-hydroxyvitamin D (25OHD) has been described in some populations in Sub-Saharan Africa (SSA) in spite of adequate sunshine all year round. There is no information on the magnitude of vitamin D deficiency among patients with stroke and other cardiovascular disease...

BACKGROUND AND AIMS Hypovitaminosis D is associated with adverse health outcomes including several bone and non-bone chronic diseases. It remains unclear whether hypovitaminosis D leads to more numerous or more severe chronic diseases. Our aim was to determine whether there was an association between serum 25-hydroxyvitamin D deficiency (i.e., 25OHD ≤25 nmol/L) and, respectively, the number and...

Literature data concerning the role of endothelium and nitric oxide in pathogenesis cardiovascular diseases, administration L-arginine as a part comprehensive therapy patients suffering from essential hypertension (EH) ischemic heart disease (IHD) are cited.Objective: to systematize current literature clinical experience with EH IHD. Conclusion. Nowadays endothelial dysfunction conception is de...

In his researches the author has made greater use of histological methods than any previous workers on the subject of deficiency diseases. From these studies and from clinical observation he has come to the conclusion that in addition to the special deficiency diseases like scurvy, beriberi, rickets, and pellagra there are many disorders of a gastro-intestinal nature that are due to defective d...

Vitamin B12 deficiency is a major public health problem: however, there is no consensus on how to diagnose this deficiency. In the present review we attempt to give a balanced update. We include only issues related to diagnosing and treating vitamin B12 deficiency in the adult population and do not cover inherited diseases of vitamin B12 deficiency except for those related to classical pernicio...

The name of lysosomal storage diseases stems from the fact that in this category of disorders specific undegraded materials are stored in the lysosomes. This is usually caused by a lysosomal enzyme deficiency and leads to a cascade of pathological outcomes. Apart from deficiency of lysosomal enzymes, lysosomal storage diseases also include deficiencies in proteins necessary for enzyme functioni...

In the 1940s and 1950s, the major nutritional diseases prevalent in large sections of the population were kwashiorkar (acute protein-energy malnutrition), keratomalacia (attributable to severe vitamin A deficiency), beri-beri (arising from vitamin B1 deficiency) and pellagra (nicotinic acid deficiency). Over the course of two to three decades, the most florid manifestations of these malnutritio...