Abstract Background The mechanisms by which the intestinal microbiome drives inflammation and disease activity in IBD is not clear. Most of current efforts developing treatments targeting are focused on microbial taxa very few developed based functions this condition. Using high-resolution functional analysis we have designed a live bacterial consortium consisting four strains with anti-inflamm...

Nanotechnology is new form of technology which has produced a great development in variousfields. Nanoparticles are of the great scientific interest as they are effectively a bridge between bulk material and atomic & molecular structures. Nanoparticles are the particle that have size 1 to 100 nm and possess due to large surface area to volume ratio & smaller size. Different types of nanom...

This paper reports a theoretical analysis of osmotic transients and an experimental evaluation both of rapid time resolution of lumen to bath osmosis and of bidirectional steady-state osmosis in isolated rabbit cortical collecting tubules exposed to antidiuretic hormone (ADH). For the case of a membrane in series with unstirred layers, there may be considerable differences between initial and s...

One of the leading issues in high-TC superconductors is the origin of the pseudogap phase in underdoped cuprates. Using polarized elastic neutron diffraction, we identify a novel magnetic order in the YBa2Cu3O6+x system. The observed magnetic order preserves translational symmetry as proposed for orbital moments in the circulating current theory of the pseudogap state. To date, it is the first ...

BACKGROUND Proton pump inhibitors (PPIs) are the most effective agents available for reducing acid secretion. They are used for medical treatment of various acid-related disorders. PPIs are used extensively and for extended periods of time in gastroesophageal reflux disease (GERD). A troublesome issue regarding maintenance therapy has been the propensity of PPI-treated patients to develop chron...

(PCR) was born in 1983 when Kary Mullis was taking a ride in the mountain range in California1,2. It is as simple as brilliant. Based on the natural ability of the polymerase enzyme to copy nucleic acids, Kary Mullis reasoned that using a heat stable polymerase it should be possible to automate the reaction to perform multiple copying events by cycling the temperature. The double stranded DNA m...

β-catenin is a multi-functional protein that plays an important role in the mature central nervous system; its dysfunction has been implicated in several neuropsychiatric disorders, including depression. Here we show that β-catenin mediates pro-resilient and anxiolytic effects in mice in the nucleus accumbens, a key brain reward region, an effect mediated by D2-type medium spiny neurons. Using ...

Amantadine acetylation was demonstrated to occur both in vivo and in vitro using transgenic male mice overexpressing spermidine/spermine N-acetyltransferase (SSAT). We previously reported that neither NAT1 nor NAT2 was responsible for catalyzing acetylation of the primary amine group of amantadine. We hypothesized that the inducible polyamine-catabolizing enzyme, SSAT, was an alternate pathway ...