We realize simultaneous quantum degeneracy in mixtures consisting of the alkali and alkaline-earth-like atoms Li and Yb. This is accomplished within an optical trap by sympathetic cooling of the fermionic isotope ⁶Li with evaporatively cooled bosonic ¹⁷⁴Yb and, separately, fermionic ¹⁷³Yb. Using cross-thermalization studies, we also measure the elastic s-wave scattering lengths of both Li-Yb co...

The overexpression of the epidermal growth factor receptor (EGFR) and HER-2 underpin the growth of aggressive breast cancer; still, it is unclear what governs the regulation of these receptors. Our laboratories recently determined that the Y-box binding protein-1 (YB-1), an oncogenic transcription/ translation factor, induced breast tumor cell growth in monolayer and in soft agar. Importantly, ...

Eukaryotic Y-box proteins are nucleic acid-binding proteins implicated in a wide range of gene regulatory mechanisms. They contain the cold shock domain, which is a nucleic acid-binding structure also found in bacterial cold shock proteins. The Y-box protein YB-1 is known to be a core component of messenger ribonucleoprotein particles (mRNPs) in the cytoplasm. Here we disrupted the YB-1 gene in...

BACKGROUND Y-box binding factor 1 (YB-1) has been associated with prognosis in many tumor types. Reduced YB-1 expression inhibits tumor cell growth, but the mechanism is unclear. METHODS YB-1 mRNA levels were compared with tumor grade and histology using microarray data from 771 breast cancer patients and with disease-free survival and distant metastasis-free survival using data from 375 of t...

CaLa2-x(MoO4)4:Ho(3+)/Yb(3+) phosphors with the doping concentrations of Ho(3+) and Yb(3+) (x = Ho(3+) + Yb(3+), Ho(3+) = 0.05; Yb(3+) = 0.35, 0.40, 0.45 and 0.50) have been successfully synthesized by the microwave sol-gel method. The modulated and averaged crystal structures of CaLa2-x(MoO4)4:Ho(3+)/Yb(3+) molybdates have been found by the Rietveld method, and the upconversion photoluminescen...

The eukaryotic Y-box-binding protein-1 (YB-1) is involved in the transcriptional and translational control of many biological processes, including cell proliferation. In clinical studies, the cellular level of YB-1 closely correlates with tumor growth and prognosis. To understand the role of YB-1 in vivo, especially in the developmental process, we generated YB-1 knock-out mice, which are embry...

Introduction: Bleomycins are DNA-binding biomolecules, which can be used as targeted therapy carriers when labeled with particle-emitters such as Yb-175. In this work the development of Yb-175 bleomycin (Yb-BLM) has been reported. Methods: Yb-175 chloride was obtained by thermal neutron irradiation (3 × 10 n.cm.s) of natural Yb2O3 samples at various neutron fluxes and irradiation times. The rad...

We review our recent work on Yb-doped and hybridstructured solid photonic bandgap fibers (Yb-HS-SPBGFs) for linearlypolarized fiber lasers oscillating in the small gain wavelength range from 1160 nm to 1200 nm. The stack-and-draw or pit-in-jacket method is employed to fabricate two Yb-HS-SPBGFs. Both of the fiber shows optical filtering property for eliminating ASE in the large gain wavelength ...

YB-1 is a DNA/RNA-binding nucleocytoplasmic shuttling protein whose regulatory effect on many DNA- and RNA-dependent events is determined by its localization in the cell. Distribution of YB-1 between the nucleus and the cytoplasm is known to be dependent on nuclear targeting and cytoplasmic retention signals located within the C-terminal portion of YB-1. Here, we report that YB-1 undergoes a sp...