Abstract Dendritic cells (DCs) are essential players in the anti-tumor immunity, which often found dysfunctional tumor microenvironment. Impairing DC antigen processing and presentation, subverts T cell priming, is one of primary mechanisms by escape immune surveillance. However, cellular factors regulating presentation DCs how render DCs’ priming capacity not fully understood. We revealed a po...

Constructing a more effective value at risk (VaR) prediction model has long been goal in financial management. In this paper, we propose novel parametric approach and provide standard paradigm to demonstrate the modeling. We establish dynamic conditional score (DCS) based on high-frequency data generalized distribution (GD), namely, GD-DCS model, improve forecasts of daily VaR. The assumes that...

the antioxidant activities of tbhq, bht and tocopherol mixtures at different concentrations (0, 100, 200, 400 mg/kg) have been evaluated by the application of differential scanning calorimetry (dsc) and rancimat apparatus. rancimat apparatus that measures the secondary oxidation products was set at 110 ⁰c with an air flow of 18-20 l/h to measure the induction period (ip) of the samples. the dsc...

in many practical distribution networks, managers face significant uncertainties in demand, local price of building facilities, transportation cost, and macro and microeconomic parameters. this paper addresses design of distribution networks in a supply chain system which optimizes the performance of distribution networks subject to required service level. this service level, which is considere...

With the advent of big data era, centers (DCs) related energy use accounts for approximately 3% global electric power consumption. As augmentation data-processing performance and thermal density in DCs, its will undoubtedly continuously burst. Meanwhile, potential safety hazards, caused by IT equipment local overheating, threaten safe operation restrict further development DCs. Thus, efficient ...

Tolerogenic dendritic cells (DCs) may be valuable in transplantation for silencing immune reaction. Macrophage colony-stimulating factor (M-CSF)/IL-4 induces differentiation of cord blood (CB) monocytes into DCs (M-DCs) with tolerogenic phenotype/function. We assessed whether factors produced by tolerogenic DCs could modulate hematopoiesis. TGF-beta1 added to CB M-DC cultures induced bona fide ...

background: tumor necrosis factor alpha (tnf-α) is a primary mediator of immune regulation and might be required in the early stages of dc development from cd34+ cells. however, details of optimal timing of exposure to tnf-α in dc development process in monocytes or non-purified hematopoitic cells are still lacking and clear benefits of this approach to the development of dcs remain to be valid...

The aim of the research is to explain how Project Management (PM) ensures accumulation, integration, utilization, and reconfiguration capabilities knowledge acquired in projects order build dynamic (DCs). This study also gives insight into PM can develop DCs through identification implementation project management opportunities. result 22 semi-structured interviews with participants from 9 comp...