نتایج جستجو برای: dcfh

تعداد نتایج: 390  

2015
Ahmed H. Arbab Mohammad K. Parvez Mohammed S. Al-Dosari Adnan J. Al-Rehaily Mohammed Al-Sohaibani Elwaleed E. Zaroug Mansour S. AlSaid Syed Rafatullah

The present study investigated the hepatoprotective and anti-HBV efficacy of Acacia mellifera (AM) leaves extracts. The crude ethanolic-extract, including organic and aqueous fractions, were tested for cytotoxicity on HepG2 and HepG2.2.15 cells (IC50=684 μg/mL). Of these, the ethyl acetate and aqueous fractions showed the most promising, dose-dependent hepatoprotection in DCFH-toxicated cells a...

2016
Orsolya Palócz Erzsébet Pászti-Gere Péter Gálfi Orsolya Farkas

This study was carried out to investigate protective effect of chlorogenic acid against lipopolysaccharide-induced inflammation and oxidative stress in intestinal epithelial cells. As a marker of inflammatory response, IL-6, IL-8, TNF-α mRNA and protein levels, furthermore, COX-2 mRNA level were followed up. Intracellular redox status and extracellular H2O2 level were also monitored by two fluo...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
Jilong Zou Yan Zhang Jiabing Sun Xiaoyan Wang Hualei Tu Shuo Geng Renhao Liu Yuxi Chen Zhenggang Bi

BACKGROUND/AIMS Osteosarcoma is the predominant form of primary bone malignancy. Although the combinational application of neoadjuvant chemotherapy and surgical resection significantly increases the survival rate, the therapeutic outcome remains unsatisfactory. Deoxyelephantopin (DET), an active ingredient of Elephantopus scaber, has been reported to have an anti-tumor effect in recent publicat...

Journal: :Molecules 2014
Jun-Min Shi Hui-Juan Huang Sheng-Xiang Qiu Shi-Xiu Feng Xu-E Li

Griffipavixanthone (GPX) is a dimeric xanthone which was isolated in a systematic investigation of Garcinia oblongifolia Champ. In this study, we investigate the effect of GPX on cell proliferation and apoptosis on human Non-small-cell lung cancer (NSCLC) cells in vitro and determine the mechanisms of its action. GPX inhibited the growth of H520 cells in dose- and time-dependent manners, with I...

2013
Martyn A. Sharpe Taylor L. Gist David S. Baskin

The role of thimerosal containing vaccines in the development of autism spectrum disorder (ASD) has been an area of intense debate, as has the presence of mercury dental amalgams and fish ingestion by pregnant mothers. We studied the effects of thimerosal on cell proliferation and mitochondrial function from B-lymphocytes taken from individuals with autism, their nonautistic twins, and their no...

Journal: :The Journal of clinical investigation 1996
I Giardino D Edelstein M Brownlee

Hyperglycemia rapidly induces an increase in intracellular advanced glycation end products (AGEs) in bovine endothelial cells, causing an alteration in bFGF activity (Giardino, I., D. Edelstein, and M. Brownlee. 1994. J. Clin. Invest. 94:110-117). Because sugar or sugar-adduct autoxidation is critical for AGE formation in vitro, we evaluated the role of reactive oxygen species (ROS) in intracel...

2017
Qian Du Ming-Ming Qian Pin-Li Liu Le Zhang Yan Wang Dong-Hui Liu

BACKGROUND In type 2 diabetes mellitus (T2DM), high-density lipoprotein (HDL) impairs its anti-atherogenic properties and even develops to a pro-inflammatory and pro-atherogenic phenotype because of abnormal compositions and modifications. In this study, we examined the effects and the related mechanisms of glycation of HDL on the proliferation and migration of vascular smooth muscle cells (VSM...

Journal: :Cancer letters 2008
Song-Shei Lin Hsuan-Pang Huang Jai-Sing Yang Jeng-Yuan Wu Te-Chun Hsia Chin-Chung Lin Cheng-Wen Lin Chao-Lin Kuo W Gibson Wood Jing-Gung Chung

Curcumin, a major component of the Curcuma species, is known to have antioxidant, anti-inflammatory properties and induce apoptosis of cancer cells, however, the precise molecular mechanisms of apoptosis in vitro are unclear. In this study, we showed that curcumin, a plant product containing the phenolic phytochemical, caused DNA damage and endoplasmic reticulum (ER) stress and mitochondrial-de...

2016
Haidong Wang Deyuan Li Zhongze Hu Siming Zhao Zhejun Zheng Wei Li

To investigate the potential therapeutic effects of polyphenols in treating Pb induced renal dysfunction and intoxication and to explore the detailed underlying mechanisms. Wistar rats were divided into four groups: control groups (CT), Pb exposure groups (Pb), Pb plus Polyphenols groups (Pb+PP) and Polyphenols groups (PP). Animals were kept for 60 days and sacrificed for tests of urea, serum b...

2018
Giulia Querio Susanna Antoniotti Federica Foglietta Cinzia M. Bertea Roberto Canaparo Maria P. Gallo Renzo Levi

Endothelial cells surround the lumen of blood vessels and modulate many physiological processes, including vascular tone, blood fluidity, inflammation, immunity and neovascularization. Many pathological conditions, including hyperglycemia, may alter endothelial function through oxidative stress, leading to impaired nitric oxide bioavailability and to the onset of an inflammatory state. As widel...

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