The aldehyde dehydrogenases from livers of the inbred mouse strains C57BL/6J, DBA/ZJ, and the F1 generation of the cross between these strains (C57BL/6J X DBA/2 J) have been purified over 60-fold. Alcohol dehydrogenase activity is not present in the purified enzyme preparation. Enzyme preparations from both strains and from the F1 cross specifically require NAD but can oxidize a variety of alde...

Previous experiments revealed a strain-dependent effect of egg cytoplasm on the developmental potential of androgenetic (two paternal genomes) mouse embryos. Eggs obtained from C57BL/6 mice supported androgenone development to the blastocyst stage at a much higher frequency than eggs from DBA/2 mice. Transient exposure of paternal pronuclei to DBA/2 egg cytoplasm also compromised development, i...

PURPOSE To document the time course of retinal dysfunction by scotopic electroretinography (ERG) and by quantitative morphology in eyes of the DBA/2NNia substrain of mouse (DBA) with inherited angle-closure glaucoma. METHODS DBA and control C57BL/6J (C57) mice were studied by ERG recordings from 5 to 15 months of age, and by morphology from 1 to 14 months of age. Scotopic ERGs were simultaneo...

Benz[a]anthracene induces aryl hydrocarbon hydroxylase activity in secondary fetal cell cultures derived from various inbred mouse strains. The maximally inducible level of hydroxylase activity from the C57BL/6N strain is 4 to 6 times higher than that from the DBA/ZN strain in cell cultures derived from the entire mouse fetus. There are no differences between C57BL/6N and DBA/2N cell cultures i...

The noise is defined as unwanted sound that causes discomfort and physical changes. This study was conducted to evaluate intensity of in the pediatric dental clinic investigate environment a dentist. Human ear shaped microphone mobile level meter were used for recording calculating noise.<br/>By according method specified by Korea Occupational Safety Health Agency (KOSHA) Ministry labor e...

This study evaluated the thickness of Dentin Bonding Agent (DBA) used for "immediate dentin sealing" of onlay preparations prior to final impression making for indirect restorations. In addition, the amount of DBA that is removed when the adhesive surface is cleaned with polishing or air abrasion prior to final cementation was evaluated. For this purpose, a standardized onlay preparation was pr...

The development of cigarette smoke-induced pulmonary changes in C57 Bl/6J and DBA/2 mice was investigated. Both strains are sensitive to oxidants and C57Bl/6J mice are moderately deficient in serum alpha1-proteinase inhibitor. Following chronic exposure to cigarette smoke, patchy emphysema was present in mice of both strains, but developed faster in DBA/2 mice. A positive reaction for mouse neu...

Diamond-Blackfan anemia (DBA) is an inherited pure red blood cell aplasia that often requires lifelong transfusional support. The origin of the imperfect erythrogenesis is not known. The existence of more than one molecular basis for DBA is indicated by its different modes of inheritance and widely variable clinical phenotypes. Several erythroid growth factors have been thought to have a role i...

We examined the hypothesis that myosin Va, by transporting purinergic vesicles to the varicosity membrane for exocytosis, plays a key role in purinergic vesicular neurotransmission. Studies were performed in wild-type (WT) and myosin Va-deficient dilute, brown, nonagouti (DBA) mice. Intracellular microelectrode recordings were made in mouse antral muscle strips. Purinergic inhibitory junction p...

The DBA/2J strain is a model for early-onset, progressive hearing loss in humans, as confirmed in the present study. DBA/2J mice showed progression of hearing loss to low-frequency sounds from ultrasonic-frequency sounds and profound hearing loss at all frequencies before 7 months of age. It is known that the early-onset hearing loss of DBA/2J mice is caused by affects in the ahl (Cdh23(ahl)) a...