This report examines the effects on hematopoietic regeneration of pegylated recombinant human megakaryocyte growth and development factor (PEG-rHuMGDF) (2.5 micrograms/ kg/d) alone and in combination with recombinant human granulocyte colony stimulating factor (rHu-GCSF) (10 micrograms/ kg/d) for 21 days in rhesus macaques receiving intense marrow suppression produced by single bolus injections...

A self-consistent method for day-time F2region modelling was applied to the analysis of Millstone Hill incoherent scatter observations during the storm period of March 16-22, 1990. The method allows us to calculate in a self-consistent way neutral composition, temperature and meridional wind as well as the ionized species height distribution. Theoretically calculated Ne(h) pro®les ®t the observ...

The effect of heat stress on oxidative stress was studied in pigeons. Pigeons were either kept at thermo neutral room at 22 C, 24 hours/day or heat stress room at 34 C for 8 hours/day followed by 22 C for o o o the rest of the day during the 40 days experiment. Increased heterophils: lymphocyte ratio was evident indicating stress in pigeons. Parallel increase in leptin, metabolites and oxidativ...

BACKGROUND Switching to cyclosporine A may result in a reversion of tacrolimus-induced diabetes mellitus. However, mechanisms underlying such a reversion are still unknown. METHODS Obese Zucker rats were used as a model for tacrolimus-induced diabetes mellitus. A cohort of 44 obese Zucker rats received tacrolimus for 11 days (0.3mg/kg/day) until diabetes development; then: (a)22 rats were eut...

The localization of V", gene regions to chromosome 2, on which the K locus is located, and to other chromosomes is described. The V", genes that have been transposed to other chromosomes are called orphons. The finding of two new V", genes on chromosome 22 is reported. A V", 11 gene of this region and two V", I genes of the Chr 1 and the cos 118 regions were sequenced. The two V", I orphon sequ...

A child with unilateral radial aplasia, asymmetry, other malformations, and severe physical and mental retardation is reported. In blood and bone marrow cultures a low mosaicism for trisomy 22 was found. In a few cells a chromosome 22 was missing. The importance of early cytogenetic analysis on large numbers of cells is emphasised, especially in cases of asymmetry where mosaicism is suspected.

Rates of lipogenesis in foetal isolated brown adipocytes from 22-day-pregnant rats were significantly increased by lactate plus pyruvate as major substrates in the incubation medium, in comparison with the endogenous rates. Insulin stimulated foetal brown-adipocyte lipogenesis, and adrenaline or noradrenaline and isoprenaline decreased lipogenesis. Glucagon had no effect on the lipogenic rate i...

This pilot study deals with the possibilities of a Continuous Glucose Monitoring System (CGMS, Minimed- Medtronic) to optimize insulin substitution. Ten persons with type 1 diabetes mellitus treated by means of an insulin pump entered the study and eight of them completed the protocol. CGMS was introduced for a period of 5 days. The standard dinner (60 g of carbohydrates) and overnight fasting ...

To determine whether abscisic acid (ABA) accumulation in endosperms of water-limited maize (Zea mays L.) plants is from synthesis in maternal plant organs or from intraendosperm synthesis, plants heterozygous for viviparous (vp) genes were self-pollinated to create endosperm genotypes capable (+/-/-; +/+/-; +/+/+) or incapable (-/-/-) of carotenoid and ABA synthesis. The mutants vp2, vp5, and v...