IMPORTANCE Hydroxychloroquine sulfate retinopathy can progress after the drug is stopped. It is not clear how this relates to the stage of retinopathy or whether early screening with modern imaging technology can prevent progression and visual loss. OBJECTIVE To determine the relationship between progression of retinopathy and the severity of disease using objective data from optical coherenc...

in tunisia, kalâat el andalous irrigated district is one of the most affected areas by salinization. the objective of this study was to predict the root zone salinity (over 10 years) in this area using the saltmod simulation model for subsurface drainage system. saltmod is based on water balance, salt balance model, and seasonal agronomic aspects. in the pilot area, irrigated vegetables crops s...

Bile Salt Transport after Selective Damage to Acinar Zone 3 Hepatocytes by Bromobenzene in the Rat, GUMUCIO, J. J., KATZ, M. E., MILLER, D. L., BALABAUD, C. P., GREENFIELD, J. M., AND WAGNER, R. M. (1979). Toxicol. Appl. Pharmacol. 50, 77-85. To quantitate the contribution of acinar zone 3 hepatocytes (centrilobular cells) to the transport of physiological concentrations of taurocholate, select...

BACKGROUND Laser Interstitial ThermoTherapy (LITT) is a well established surgical method. The use of LITT is so far limited to homogeneous tissues, e.g. the liver. One of the reasons is the limited capability of existing treatment planning models to calculate accurately the damage zone. The treatment planning in inhomogeneous tissues, especially of regions near main vessels, poses still a chall...

Spinal cord injury (SCI) provokes an inflammatory response that generates substantial secondary damage within the cord but also may contribute to its repair. Anti-inflammatory treatment of human SCI and its timing must be based on knowledge of the types of cells participating in the inflammatory response, the time after injury when they appear and then decrease in number, and the nature of thei...

Quantifying fault damage zones provides a window into stress distribution and rheology around faults. International Ocean Discovery Program (IODP) Expeditions 372/375 drilled an active thrust splay within the Hikurangi subduction margin. The fault, which is hosted in Pleistocene clastic sediments, surrounded by brittle fractures faults as well ductile deformation features. We find that fracture...

Penetrating neck wounds complicate approximately 10% of all trauma presentations. While they are most commonly associated with violent acts, they are also encountered in road traffic collisions andotheraccidents. Theadverse relationship between alcohol and trauma is well-documented. The mechanism of penetration is important in determining the extent of damage and treatment options. Ballistic mi...

Xiaowan Hydropower station’s dam located in south west of China is the second highest arch dam in the world (h = 292 m), its foundation is based on brittle rocks of biotite granite gneiss and amphibolites plagioclase gneiss. A largescale excavation around the foundation of the dam was conducted, near to 90 meters horizontal depth excavation and 130 meters vertical depth excavation, so the found...