The use of irinotecan to treat metastatic colorectal cancer (CRC) is limited by unpredictable response and variable toxicity; however, no reliable clinical biomarkers are available. Here, we report a study to ascertain whether irinotecan-induced DNA damage measures are suitable/superior biomarkers of irinotecan effect. CRC-cell lines (HCT-116 and HT-29) were treated in vitro with irinotecan and...

A SU (4) ⊗ O(3) scheme for nonstrange baryons Abstract. We show that nonstrange baryon resonances can be classified according to multiplets of SU (4)⊗ O(3). We identify spectral regularities and degeneracies that allow us to predict the high spin spectrum from 2 to 3 GeV.

We present a microscopic index formula for the degeneracy of dyons in four-dimensional N = 4 string theory. This counting formula is manifestly symmetric under the duality group, and its asymptotic growth reproduces the macroscopic Bekenstein-Hawking entropy. We give a derivation of this result in terms of the type II five-brane compactified on K3, by assuming that its fluctuations are describe...

We have designed, prototyped, and evaluated the Legend file system, which exploits the ability to regenerate lost files to improve reliability. Unlike RAID-5 and RAID-6, Legend degrades gracefully as the number of failed storage devices increases. Legend also mitigates the high storage capacity overhead imposed by n-way replications. Combined with existing methods, Legend can form another line ...

Hisakazu Minakata, Hiroshi Nunokawa, Stephen Parke 1 Department of Physics, Tokyo Metropolitan University 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, Japan [email protected] 2 Instituto de F́ısica Teórica, Universidade Estadual Paulista Rua Pamplona 145, 01405-900 São Paulo, SP Brazil [email protected] 3 Theoretical Physics Department, Fermi National Accelerator Laboratory P.O.Box ...

72 h The primary function of the mitochondrial respiratory chain is to generate energy in the form of ATP via the four complexes of the electron transport chain and the ATP synthetase. Damage to one or more of the respiratory chain complexes may therefore result in depletion of cellular energy reserves and cell death. There is increasing evidence that defects in mitochondrial energy metabolism ...

Symbolic perturbation by innnitely small values removes degeneracies in geometric algorithms and enables programmers to handle only generic cases: there are a few such cases, whereas there are an overwhelming number of degenerate cases. Current perturbation schemes have limitations, presented below. To overcome them, this paper proposes to use an-arithmetic, i.e. to represent in an explicit way...

Introduction: Liver ischemia/reperfusion (IR) is a major clinical problem, which occurs during several conditions such as liver damage, trauma and transplantation. Recent studies indicate that IR-induced acute liver failure causes injuries of distant organs such as heart and lungs by systematic inflammatory responses. Therefore, in the present study, effects of hepatic IR induction were stud...