the probable maximum precipitation (pmp) is the greatest depth of precipitation for a given duration that is physically possible over a given size storm area at a particular geographical location at a certain time of the year. in this study a physically based method was compared with a statistical procedure to calculate pmp in the southwest arid regions of iran. in order to estimate pmp using a...

Based on our recent finding that cardiac myosin binding protein C (cMyBP-C) phosphorylation affects muscle contractility in a site-specific manner, we further studied the force per cross-bridge and the kinetic constants of the elementary steps in the six-state cross-bridge model in cMyBP-C mutated transgenic mice for better understanding of the influence of cMyBP-C phosphorylation on contractil...

TGF-β/BMP (bone morphogenetic protein) signaling pathways play conserved roles in controlling embryonic development, tissue homeostasis, and stem cell regulation. Inhibitory Smads (I-Smads) have been shown to negatively regulate TGF-β/BMP signaling by primarily targeting the type I receptors for ubiquitination and turnover. However, little is known about how I-Smads access the membrane to execu...

Vulnerability of power grid is a critical issue in power industry. In order to understand and reduce power grid vulnerability under threats, existing research often employs defender-attacker-defender (DAD) models to derive effective protection plans and evaluate grid performances under various contingencies. Transmission line switching (also known as topology control) is an effective operation ...

The aim of this study was to determine reliability and validity of the Spanish version of the Disability Assessment for Dementia Scale (DAD-E) in the following areas: content, response process, internal structure, and relation to other constructs.We designed a cross-sectional observational study. The DAD-E was administered to 132 participants diagnosed with mild cognitive decline, prodromal Alz...

Descending aortic dissection (DAD) is associated with high morbidity and mortality rates. Aortic wall stiffness is a variable often altered in DAD patients and potentially involved in long-term outcome. However, its relevance is still mostly unknown. To gain more detailed knowledge of how wall elasticity (compliance) might influence intraluminal haemodynamics in DAD, a lumped-parameter model wa...

Standard provisions for wind loads on buildings have traditionally been based on summary tables and/or plots suitable for slide-rule calculations, leading to a discrepancy between the accuracy of wind loads defined by such tables and plots and the accuracy of current methods for stress computation. Advances in computational power now make it possible to reduce this discrepancy and achieve struc...

Zhengtian pills (ZTPs) are traditional Chinese medicine (TCM) which have been commonly used to treat headaches. Volatile components of ZTPs extracted by ethyl acetate with an ultrasonic method were analyzed by gas chromatography mass spectrometry (GC-MS). Twenty-two components were identified, accounting for 78.884% of the total components of volatile oil. The three main volatile components inc...

Current specification of address configuration mandates the execution of the Duplicate Address Detection (DAD) mechanism to prevent address duplication. However, a proper support for real time multimedia applications in mobile IPv6 nodes is undermined by the disruption imposed by DAD. In order to overcome this limitation, the usage of randomly generated IPv6 Interface Identifiers without previo...

The enzyme 2,4'-dihydroxyacetophenone dioxygenase (DAD) catalyses the conversion of 2,4'-dihydroxyacetophenone to 4-hydroxybenzoic acid and formic acid. This enzyme is a very unusual dioxygenase in that it cleaves a C-C bond in a substituent of the aromatic ring rather than within the ring itself. Whilst it has been shown that DAD is a tetramer in solution, the recently solved crystal structure...