Polypharmacology (the ability of a drug to affect more than one molecular target) is considered a basic property of many therapeutic small molecules. Herein, we used a chemical genomics approach to systematically analyze polypharmacology by integrating several analytical tools, including the LINCS (Library of Integrated Cellular Signatures), STITCH (Search Tool for Interactions of Chemicals), a...

The CD25-binding antibody daclizumab high-yield process (DAC HYP) is an interleukin (IL)-2 signal modulating antibody that shares primary amino acid sequence and CD25 binding affinity with Zenapax®, a distinct form of daclizumab, which was approved for the prevention of acute organ rejection in patients receiving renal transplants as part of an immunosuppressive regimen that includes cyclospori...

The biogenesis and assembly of photosynthetic multisubunit protein complexes is assisted by a series of nucleus-encoded auxiliary protein factors. In this study, we characterize the dac mutant of Arabidopsis (Arabidopsis thaliana), which shows a severe defect in the accumulation of the cytochrome b(6)/f complex, and provide evidence suggesting that the efficiency of cytochrome b(6)/f complex as...

Purpose: Azanucleoside DNA methyltransferase (DNMT) inhibitors are currently approved by the U.S. Food and Drug Administration for treatment of myelodysplastic syndrome. The relative contributions of DNMT inhibition and other off-target effects to their clinical efficacy remain unclear. Data correlating DNA methylation reversal and clinical response have been conflicting. Consequently, it is ne...

This paper presents a new object oriented framework DAMPVM/DAC which is implemented on top of DAMPVM and provides automatic partitioning of irregular divide-and-conquer (DAC) applications at runtime. The processes are then mapped dynamically to processors taking into account their speeds and even loads by other user processes. The paper presents the programming interface (API) of the framework,...

This special project presents a 10-Bit 1Gs/s 1.2V/3.3V Digital-to-Analog Converter using1 Poly 9 Metal SAED 90-nm CMOS Technology intended for mixed-signal and power IC applications. To achieve maximum performance with minimum area, the DAC has been implemented in 6+4 Segmentation. The simulation results show a static performance of ±0.56 LSB INL and ±0.79 LSB DNL with a total layout chip area ...

This paper presents a new DAC design strategy to achieve a wideband dynamic linearity by increasing the bandwidth of the output impedance. In order to reduce the dominant parasitic capacitance of the conventional matrix structure, all the cells associated with a unit current source and its control are stacked in a single column very closely (stacked unit cell structure). To further reduce the p...

We describe a floating-gate trimmed, 14-bit, 250Ms/s current-steered DAC fabricated in a 0.25μm CMOS logic process. We trim the static INL to ±0.3LSB using analog charge stored on floating-gate pFETs. The DAC occupies 0.44mm of die area, consumes 53mW at 250MHz, allows on-chip electrical trimming, and achieves 72dB SFDR at 250Ms/s. Introduction Emerging standards for communications systems requ...

A compact and low-power design of a 12-bit binary-weighted current-steering DAC is presented. Instead of 4096 unit current cells, the proposed design uses 192 unit current sources with two reference currents. The silicon area of the generation circuit of two reference currents is very compact as well. The area of the total current source arrays is smaller than four times the area of 6-bit curre...

This paper proposes a built-in self-test (BIST) scheme for noise-tolerant testing of a digital-to-analogue converter (DAC). The proposed BIST calculates the differences in output voltages between a DAC and test modules. These differences are used as the inputs of an integrator that determines integral nonlinearity (INL). The proposed method has an advantage of random noise cancelation and achie...