Background: Massularia acuminata has been claimed to be used in managing several ailments in folk medicine and in some instances substantiated with scientific data. This however has been without recourse to its safety. Therefore, aqueous stem extract of M. acuminata was evaluated for its effects on some function indices of the liver of male rats. Methods: Sixty, male rats were grouped into 4 ...

1. An injection of D-galactosamine at the same time as an injection of dexamethasone inhibits the increase of rat liver tyrosine aminotransferase activity normally observed following injection of dexamethasone alone. The galactosaminemediated inhibition is dose dependent: a 50% inhibition of the increase of enzyme activity is observed at 10 mg of galactosamine .HCl per 100 g of body weight, and...

1. An injection of D-galactosamine at the same time as an injection of dexamethasone inhibits the increase of rat liver tyrosine aminotransferase activity normally observed following injection of dexamethasone alone. The galactosaminemediated inhibition is dose dependent: a 50% inhibition of the increase of enzyme activity is observed at 10 mg of galactosamine .HCl per 100 g of body weight, and...

The gene for thermostable D-amino acid aminotransferase from a thermophile, Bacillus species YM-1 was cloned and expressed efficiently in Escherichia coli. The entire covalent structure of the enzyme was determined from the nucleotide sequence of the cloned gene and mostly confirmed by amino acid sequences of tryptic peptides from the gene product. The polypeptide is composed of 282 amino acid ...

BACKGROUND The liver is crucial for 25-hydroxyvitamin D (25(OH)D) metabolism, and vitamin D deficiency is highly prevalent in patients with cirrhosis and predicts adverse outcomes. We aimed to evaluate whether vitamin D supplementation in patients with cirrhosis is effective in increasing 25(OH)D serum concentrations. Secondary outcome measures included liver function tests (aspartate aminotran...

Background: Myocardial infarction (MI) is one of the most important causes of death worldwide. The effect of flunixin meglumine (FM) on MI is unknown. We investigated the protective effect of FM on the serum biochemical profile, malondialdehyde (MDA), and heart histology changes induced by isoproterenol (ISO) in adult male rats. Methods: Rats were randomly divided into four groups of six eac...

HYBRIDS FROM A CROSS OF RAT HEPATOMA CELLS WITH DIPLOID EPITHELIAL CELLS FROM RAT LIVER HAVE BEEN STUDIED WITH RESPECT TO KARYOTYPE AND EXPRESSION OF TWO FUNCTIONS LIMITED TO THE HEPATOMA PARENT: high level of the enzyme tyrosine aminotransferase (EC 2.6.1.5; L-tyrosine:2-oxoglutarate aminotransferase) and its inducibility with steroid hormones. The hybrids that contain the complete chromosomal...