BACKGROUND Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in children and represents approximately 25% of cancer diagnoses among those younger than 15 years of age. MATERIALS AND METHODS This study investigated alterations in the displacement loop (d-loop) region of mitochondrial DNA (mtDNA) as a risk factor and diagnostic biomarker for early detection and diagnosis of...

Mitochondrial genome alternations may be involved in carcinogenesis. The noncoding region of the mitochondrial DNA (mtDNA) displacement loop (D-loop) has emerged as a mutational hotspot. Using data from a population-based case-control study conducted among Chinese women in Shanghai, we evaluated associations of breast cancer risk and survival with the mtDNA D-loop (CA)(n) dinucleotide repeat po...

alzheimer’s disease (ad) is the most common form of dementia in the elderly in which interplay between genes and the environment is supposed to be involved. mitochondrial dna (mtdna) has the only non-coding regions at the displacement loop (d-loop) region that contains two hypervariable segments (hvs-i and hvs-ii) with high polymorphism. mtdna has already been fully sequenced and many subsequen...

The performance of a forced-liquid Vertical Tubular Loop Bioreactor (VTLB), a forced-liquid Horizontal Tubular Loop Bioreactor (HTLB) and a gas-induced External Airlift Loop Bioreactor (EALB) were compared for production of biomass from natural gas. Hydrodynamic characteristics and mass transfer coefficients were determined as functions of design parameters, physical properties of gases as ...

The accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers, and their association with cancer risk and disease outcome has been extensively identified. In the present study, we investigated the association between age-at-onset and SNPs in the mitochondrial D-loop using a population-base...

flip-flop circuit technique has been designed. CMOS new flip-flop circuit with CMOS domino logic which, All the flip-flops were designed using UMC 180. Recognize standard circuit symbols for D Type flip-flops. though can be largely prevented by using the Edge Triggered D Type flipflop illustrated in Fig 5.3.3. locked loop, using 32 nm CMOS technology. Here we design D flipflop for Phase locked ...

the performance of a forced-liquid vertical tubular loop bioreactor (vtlb), a forced-liquid horizontal tubular loop bioreactor (htlb) and a gas-induced external airlift loop bioreactor (ealb) were compared for production of biomass from natural gas. hydrodynamic characteristics and mass transfer coefficients were determined as functions of design parameters, physical properties of gases as well...

The C/D guide RNAs predicted from the genomic sequences of three species of Pyrococcus delineate a family of small non-coding archaeal RNAs involved in the methylation of rRNA and tRNA. The C/D guides assemble into ribonucleoprotein (RNP) that contains the methyltransferase. The protein L7Ae, a key structural component of the RNP, binds to a Kink-turn (K-turn) formed by the C/D motif. The K-tur...