introduction: ischemia leads to loss of neurons by apoptosis in specific brain regions, especially in the hippocampus. the purpose of this study was investigating the effects of exercise preconditioning on expression of bax, bcl-2, and caspase-3 proteins in hippocampal ca1 neurons after induction of cerebral ischemia. methods: male rats weighing 260-300 g were randomly allocated into three grou...

1-[4-(2-alkylaminoethoxy)phenylcarbonyl]-3,5-bis(arylidene)-4-piperidones are a novel class of potent cytotoxic agents. these compounds demonstrate low micromolar to submicromolar ic50 values against human molt 4/c8 and cem t-lymphocytes and murine leukemia l1210 cells. in this study, a comparative qsar investigation was performed on a series of 3,5-bis(arylidene)-4-piperidones using different ...

background: glioblastoma is the most common and most malignant cancer of central nervous system. targeted radiotherapy is an effective method toward its treatment. iododeoxyuridine (iudr) is a halogenated thymidine analogue known to be effective as a radiosensitizer in human cancer therapy. in this study we have evaluated the combination effects of 2-methoxyestradiol, an inhibitor of hypoxia in...

nanoparticles of coordination polymer [co2(pydc)2(h2o)6]n.2n h2o [h2pydc = pyridine-2,5-dicarboxylic acid] have been synthesized by sonochemical method and characterized by elemental analysis, infrared spectroscopy, powder x-ray diffraction, scanning electron microscopy, dls particle size analysis and tga/dta. the structure of single crystalline coordination polymer developed from nanosized coo...

a m i t r a z, a n i ns e c t i c i d e /a ca ri c i de of the f o r m a m i d i n e p e st i c i d e s group, is a ? 2 a d r e n e r g i c ag on i st a nd of t he a m i d i ne c h e m i ca l f a m il y generally us e d to c o n t r ol animal e c top a r a s i t e s. poisoning due to am i t r a z i s r a r e and characterized by c e nt r a l n e r v ous s y st e m a nd r e sp ir a to r y d e p ...

allergic asthma is a complex and chronic inflammatory airway disease. interleukin-17 is a pro-inflammatory cytokine which plays critical role in the pathogenesis of allergic asthma. it has been reported that β-arrestin2 regulated the development of allergic asthma at a proximal step in the inflammatory cascade. in this study, the influence of β-arrestin2 on interleukin-17 production and express...

honey and royal jelly are complex heterogeneous mixtures of flower s’ nectar sugars proteins and bees’ glandular secretions. royal jelly is the hypo-pharyngeal gland excretion of the young worker honeybees (apis mellifera). the wonderful effects of royal jelly on the sexual ability and maturity of the queen has been an interesting topic and controversial issue for researchers for many years. th...

hematopoietic cord blood (cb) stem cell transplantation has more advantages to other cell sources because of lower graft versus host disease (gvhd). interleukin-15(il-15) is an immunoregulatory cytokine, known to enhance cytolytic function of cord natural killer (nk) cells. the aim of this study was to investigate the effect of il-15 on nk cytotoxicity simultaneously in different cell death sta...

the abscission of alstroemeria petals is the serious problem at the industry of cut flowers of this plant. in this study, cut alstroemeria cv. bridal flowers were pulsed with solutions containing natural essential oil carvacrol, gibberellic acid and benzyladenine (50 and 100 mg l-1), -5-sulfosalicylic acid (1 and 1.5 mm) and sucrose (5 and 10%) for 24 hours. the distilled water was used as cont...

abstract in the present set of investigations, the anti-mutagenic and anti-cytotoxic effects of aqueous rosemary leaves extract (re) beside the dose dependency of these effects on male mice bone marrow and germ cells have been evaluated using in vivo cytogenetic, histopathologic and apoptotic assays, as well as biochemical analysis. doxorubicin (dxr), a well-known mutagen and cytotoxic agent, w...