This study examined the microbial transformation of carbazole (CZ) by an isolated bacterium that can use CZ as a sole carbon and nitrogen source. The strain identified as Pseudomonas stutzeri produced a large amount of anthranilic acid (AA) from CZ in the medium containing a nonionic surfactant. In dialysis culture using ion-exchange resin, 7.9 g/liter (58mm) of AA was accumulated from 15g/lite...

Mesoporous MCM-41 silicas anchored with sulfonic acid (–SO3H) groups (denoted MSN-SA) via postsynthesis modification are very effective for the Beckman rearrangement. A simple and convenient procedure for conversion of a variety oximes to their corresponding amides and lactams has been developed. The reaction was carried out in the presence of MSN-SA as the catalyst. The best results for conver...

Let X be a Riemann surface equipped with a projective structure (i.e., a covering by coordinate charts such that the transition functions are of the form z 7−→ (az + b)/(cz + d)). Let L be a line bundle on X such that L = TX . Let J (L) −→ X denote the jet bundle of order m for the line bundle L. For i ≥ j, there is a natural restriction homomorphism from J (L) onto J (L). We prove that for any...

Two families of protein kinases that are closely related to Ste20 in their kinase domain have been identified - the p21-activated protein kinase (Pak) and SPS1 families [1-3]. In contrast to Pak family members, SPS1 family members do not bind and are not activated by GTP-bound p21Rac and Cdc42. We recently placed a member of the SPS1 family, called Misshapen (Msn), genetically upstream of the c...

Striatal projecting neurons, known as medium spiny neurons (MSNs), segregate into two compartments called matrix and striosome in the mammalian striatum. The matrix domain is characterized by the presence of calbindin immunopositive (CB+) MSNs, not observed in the striosome subdivision. The existence of a similar CB+ MSN population has recently been described in two striatal structures in male ...

Most problems in algebra, at some stage, must consider algebraic equations. Sometimes solving them, other times producing them – so their existence manifests a desired structure. Akin to doing differential equations, a researcher in algebraic equations must specialize to get somewhere. My speciality is algebraic equations in two variables, say w and z, where one variable, say z, interprets as a...

Elevated oxidative stress has been characterized in numerous disorders including systemic hypertension, arterial stiffness, left ventricular hypertrophy (LVH) and heart failure. The peroxisome proliferator activated receptor gamma (PPARgamma) ameliorates oxidative stress and LVH. To test the hypothesis that PPARgamma decreased LVH and cardiac fibrosis in chronic pressure overload, in part, by i...

Cruzipain (Cz) is the major cysteine protease of the protozoan Trypanosoma cruzi, etiological agent of Chagas disease. A conformation-independent classifier capable of identifying Cz inhibitors was derived from a 163-compound dataset and later applied in a virtual screening campaign on the DrugBank database, which compiles FDA-approved and investigational drugs. 54 approved drugs were selected ...

The paper describes the process of building the Czech Digital Mathematics Library (DML-CZ) upon DSpace System. At first, the DML-CZ will be briefly introduced. Then we will describe DSpace system and its architecture together with Manakin—a system for building user interface above DSpace. The first technical part of the paper will be about mapping DML-CZ structure onto DSpace structures and abo...