bacground: evidence from several lines of investigations suggests that toll-like receptor 4 (tlr4) is involved in atherosclerosis as a bridge between innate and acquired immunity. percutaneous coronary intervention (pci) can trigger inflammation through activation of human tlr4 (htlr4) on monocytes. hydrocortisone as an anti-inflammatory and immuno-suppressant agent has multiple mechanisms of a...

conclusions we have highlighted the role of rns3 plus rnt-gp96 mediated by α5integrin in producing il-12 and tnfα. it can be suggested that rnt-gp96 could enhance immunity characteristic of rns3 protein via production of pro-inflammatory cytokines. results our results showed that rnt-gp96 alone significantly increases the expression level of il-12, tnfα and α5integrin in thp-1 macrophages and d...

objective(s): in the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (egcg) on lipopolysaccharide (lps)-induced hepatotoxicity by using hep3b human hepatoma cells. specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of lps-associated cytotoxicity. consequently, the hepatocellu...

background: multiple sclerosis (ms) is a demyelinating disease of the central nervous system and cytokines may play a role in the development of ms lesions. objective: to determine levels of different cytokines in patients with relapsing-remitting ms (rr-ms) compared to healthy controls. methods: profiles of pro-inflammatory, th1-, th2-, and th17-related cytokines were compared by quantitative ...

BACKGROUND The behavior of tumor cells is influenced by the composition of the surrounding tumor environment. The importance of ascites in ovarian cancer (OC) progression is being increasingly recognized. The characterization of soluble factors in ascites is essential to understand how this environment affects OC progression. The development of cytokine arrays now allows simultaneous measuremen...

Background: Diabetic retinopathy is a progressive vision threatening complication of diabetes. Raised plasma level of tumor necrosis factor and other cytokines are accepted as the key in early events in the development of vascular disease. Objective: The aim of this study was to assess the level of some cytokines in diabetic retinopathy and its effect on the severity of diabetic retinopathy. Pa...

Background: Recent clinical studies have reported that some cytokines are associated with lung cancer prognosis and mortality. However, the relationship between outcomes in severe patients was unclear. IL-6 as an important cytokine inflammation, expression level unknown.

Background: It has been established that the level of some inflammatory cytokines increases in celiac disease (CD) and non-celiac gluten sensitivity (NCGS) in comparison with healthy subjects. Therefore, the primary interest in our research was proposing an accurate tool to diagnose patients with CD and NCGS from healthy individuals in an Iranian population. Methods: The serum samples were exam...