While voluminous studies have attributed the continuing decline of institutional trust to political corruption, the link between corruption and institutional trust in Asia has yet been explored systematically. Testing the effect of corruption on institutional trust is theoretically important and empirically challenging, since many suggests that contextual factors in Asia such as political cultu...

Metoprolol, a commonly prescribed β-blocker, is primarily metabolized by cytochrome P450 2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Several smaller studies have shown that metoprolol pharmacokinetics is influenced by CYP2D6 genotype and metabolizer phenotype. To increase robustness of metoprolol pharmacokinetic estimates, a systematic review and meta-analysis of pharmacokin...

The physical characteristics of landscapes place fundamental constraints on vegetation growth and ecosystem function. In actively eroding landscapes, many of these characteristics are controlled by long-term erosion rates: increased erosion rates generate steeper topography and reduce the depth and extent of weathering, limiting moisture storage capacity and impacting nutrient availability. Des...

The tissues of hepatocellular carcinoma were operatively resected from six patients. All four components of the systems of microsomal cytochrome P-450-linked monooxygenase of the tissues were investigated and compared to those of normal liver tissue. The concentrations of cytochromes P-450, P-420 and b5 were measured optically and the concentrations of all components except cytochrome P-450 wer...

The open oceans comprise most of the biosphere, yet patterns and trends of species diversity there are enigmatic. Here, we derive worldwide patterns of tuna and billfish diversity over the past 50 years, revealing distinct subtropical "hotspots" that appeared to hold generally for other predators and zooplankton. Diversity was positively correlated with thermal fronts and dissolved oxygen and a...

This article uses the mass-media career of the British psychiatrist David Stafford-Clark (1916-1999) as a case study in the exercise of cultural authority by celebrity medical professionals in post-war Britain. Stafford-Clark rose to prominence in the mass media, particularly through his presenting work on medical and related topics for BBC TV and Radio, and was in the vanguard of psychiatrists...

Earth’s landscape is continually evolving as land uplifted by tectonic and volcanic processes is eroded by water, ice, and wind. On Earth, the dominant landforms have been produced by the action of rivers and glaciers transporting material from mountains to the sea. The amount and proportion of water and ice available for changing the landscape are both sensitive to climatic regime, so that a s...

We analyze the dynamics of public and private sector employment, using the natural experiment provided by the partial privatization of the Bangladeshi jute industry. A differences-in-differences approach allows us to infer ownership effects. Although the public sector had substantial excess employment of workers initially, this excess was substantially eroded by the end of the period we study. ...

Medical influence on health service management at district level could be eroded as the new Griffiths management arrangements are introduced by district health authorities. Most districts are changing the composition and functions of the district management team to accommodate their new general managers. District general managers are required to prepare new management arrangements for their dis...