The three antihistaminic drugs investigated are of diverse chemical types, and many chemical methods have been reported for their assay. Cyproheptadine hydrochloride (CPH) is a serotonin and a histamine antagonist with anticholinergic and sedative effects. It also blocks voltage sensitive calcium channels in pancreatic islet cells and smooth muscle. CPH is also used as an appetite stimulant to ...

INTRODUCTION: 5-HT2A receptors are of significant clinical interest because of their potential involvement in mediating a variety of physiological functions, including platelet aggregation, thrombus formation, coronary artery spasm, vascular smooth muscle contraction, appetite, sleep, cognition, perception, mood, and other central nervous system functions. Different antagonists such as ketanser...

Objective: To report a case of serotonin syndrome, with episodic worsening course, which responded to treatment with cyproheptadine. Case Report: A 56 year old male, was diagnosed as a case of bipolar affective disorder, hypertension and generalized seizure disorder. While receiving a combination of lithium carbonate 750 mg/d, amlodipine 10 mg/d, phenytoin 300mg/d, sertraline 100 mg/d, trazodon...

INTRODUCTION Calotropis procera is known to produce contact dermatitis and the latex of this plant produces intense inflammation when injected locally. However, the precise mode of its pro-inflammatory effect is not known. In present study we have pharmacologically characterized the inflammation induced by latex of C. procera in a rat paw edema model and determined the role of histamine in late...

Acute pancreatitis was induced in mice by feeding with a choline-deficient ethionine-supplemented diet. All the mice developed acute pancreatitis, and approximately 80% of them died within 4 days. Stereomicroscopic and light microscopic examinations revealed that pancreatic necrosis and circulatory disturbance that were not apparent on day 1 were increased markedly on days 2 and 3. Serum levels...

In the present study we have utilized the Allium cepa root tip meristem model to evaluate the cytotoxic and anti-mitotic activities of latex of Calotropis procera (DL) and podophyllotoxin. Standard cytotoxic drug cyclophosphamide and non-cytotoxic drugs cyprohcptadine and aspirin served as controls. Like cyclophosphamide, both DL and podophyllotoxin significantly inhibited the growth of roots a...