نتایج جستجو برای: cyp27b1
تعداد نتایج: 360 فیلتر نتایج به سال:
Abstract Background and Aims Alterations of vitamin D metabolism are ubiquitous in patients with chronic kidney disease (CKD) a key feature the syndrome CKD-mineral bone disorder. A central paradigm is that kidneys only relevant source activation for systemic effects. However, various cells tissues exhibit CYP27B1 activity capable producing 1.25(OH)2D, which could contribute to circulating pool...
BACKGROUND Mendelian randomization (MR) studies use genetic variants mimicking the influence of a modifiable exposure to assess and quantify a causal association with an outcome, with an aim to avoid problems with confounding and reverse causality affecting other types of observational studies. AIM We evaluated genetic markers that index differences in 25-hydroxyvitamin D (25(OH)D) as instrum...
BACKGROUND Slightly more than 5 % of the United States population heavily consumes ethanol, i.e., more than 14 drinks for men and 7 drinks for women a week. Chronic ethanol consumption can result in increased liver disease, reduced recovery from burn injury, and more frequent and severe respiratory infections. Chronic ethanol over-consumption also leads to vitamin D dysmetabolism and depletion....
We recently discovered that chronic high fructose intake by lactating rats prevented adaptive increases in rates of active intestinal Ca(2+) transport and in levels of 1,25-(OH)2D3, the active form of vitamin D. Since sufficient Ca(2+) absorption is essential for skeletal growth, our discovery may explain findings that excessive consumption of sweeteners compromises bone integrity in children. ...
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