Injection of botulinum toxin is currently the most common cosmetic procedure in the United States, and in recent years it has become-together with dermal fillers-the mainstay of therapy for the prevention and treatment of facial aging. However, in some cases the treatment may lead to a somewhat unnatural appearance, usually caused by loss of facial expression or other telltale signs. In the pre...

Pressure ulcers with undermined edges are generally hard to treat and may require surgical debridement and flap coverage. A woman with a 5-month history of a non-healing, undermined, sacro-coccygeal pressure ulcer presented for care at the author's wound care center. Because traditional wound care had failed and surgical debridement and repair was contraindicated due to her overall poor general...

The list of injectable skin fillers available for soft tissue augmentation is constantly growing, giving aesthetic surgeons more options in the treatment of scars, lines, and wrinkles. Each type of filler is distinct with regard to intended use, placement technique, duration in tissue, ease of use, and cost. Physicians who are well acquainted with the strengths and weaknesses of each class of f...

The aging midface has long been overlooked in cosmetic surgery. Our understanding of facial aging in terms of 3 dimensions has placed increased importance on volume restoration. Although an "off-label" indication for most fillers in this facial region, volumization of the midface with injectable fillers is usually a safe and straightforward procedure technically. Injectors, nevertheless, need t...

Hyaluronidases, a family of enzymes that are able to degrade hyaluronic acid (HA), are employed in medicine to increase drug diffusion and reverse the effects of HA filler injections. Hyaluronidases are able to dissolve subcutaneous nodules or to correct excessive quantities of injected filler. Knowledge of the use, methods of application, and adverse effects of hyaluronidases is essential for ...

Neurotoxins and fillers continue to remain in high demand, comprising a large part of the growing business of cosmetic minimally invasive procedures. Multiple Food and Drug Administration-approved safe yet different products exist within each category, and the role of each product continues to expand. The authors review the literature to provide an overview of the use of neurotoxins and fillers...

Over the years, many materials have been used as fillers in rubber compounds. In this sense, filler is a diluent and is used primarily to lower volume cost. With use, all fillers modify certain physical properties of the compound in addition to lowering cost. Therefore, lower cost is generally achieved at the expense of other desirable properties and all compounds are compromises with various t...

In second language input studies, speaking speed is regarded as one of the most influential factors in comprehension. However, research in this area has mainly been conducted on written texts read aloud. The present study investigated temporal variables, such as articulation rate and ratio and frequency of fillers and silent pauses, in three university lectures given in Japanese. It was found t...

The focus of this paper is artificial voices with different personalities. Previous studies have shown links between an individual’s use of disfluencies in their speech and their perceived personality. Here, filled pauses (uh and um) and discourse markers (like, you know, I mean) have been included in synthetic speech as a way of creating an artificial voice with different personalities. We dis...