نتایج جستجو برای: cyanex 302
تعداد نتایج: 6187 فیلتر نتایج به سال:
Computing power and sophisticated data acquisition mask the fact that, in many sciences and engineering, the balance between theory and experiment is getting increasingly out of whack. The imbalance becomes an even greater concern in light of the increasingly complex natural systems science now confronts and the increasingly complex and interdependent socio-technical systems modern engineering ...
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Cellular transformation is initiated by the activation of oncogenes and a closely associated developmental reprogramming of the epigenetic landscape. Transcription factors, regulators of chromatin states and microRNAs influence cell fates in development and stabilize the phenotypes of normal, differentiated cells and of cancer cells. The miR-302/367 cluster, predominantly expressed in human emb...
From Heterotrophism to Autotrophism .......... ............................... 299 New Catalysts in CO.-Fixing Autotrophs ......... .............................. 300 RuDP carboxylase and phosphoribulokinase ....... .......................... 300 Properties of RuDP Carboxylase............................................... 300 Kinetic response to substrates ........................................
Purpose: Tumor hypoxia underlies treatment failure and yields a more aggressive, invasive, and metastatic cancer phenotype. TH-302 is a 2-nitroimidazole triggered hypoxia-activated prodrug of the cytotoxin bromo-isophosphoramide mustard (Br-IPM). The purpose of this study is to characterize the antitumor activity of TH-302 and investigate its selective targeting of the hypoxic cells in human tumor
BACKGROUND Features of the tumor microenvironment influence the efficacy of cancer nanotherapeutics. The ability to directly radiolabel nanotherapeutics offers a valuable translational tool to obtain biodistribution and tumor deposition data, testing the hypothesis that the extent of delivery predicts therapeutic outcome. In support of a first in-human clinical trial with (64)Cu-labeled HER2-ta...
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