Many examples of multiple melanotic sarcoma of the skin have been recorded, notably by Kaposi, Hardavvay, and G. H. Fox. Hardaway has illustrated his cases by two excellent chromolithographs, in the Journal of Cutaneous Diseases for 1883, 1884, and Fox represents an instance where the tumours could be counted by hundreds in his photographs of skin diseases. But solitary melanotic sarcomata are ...

An adult native cock (Gallus gallus domesticus) referred to the aviary clinic with multiple different sizes of round dermal nodules. The bird died few days later, and was then submitted for further evaluation. Macroscopic and microscopic examinations as well as a PCR test were done to identify type and cause of the tumor. In histopathological assessment of biopsy specimen, it consisted of inter...

Angioimmunoblastic Lymphadenopathy (AIL) is an uncommon disorder which begins  with constitutional symptoms. The majority of the patients .has generalized l?7111ph­ adenopathy, , hepatosplenomegaly and about 40% show cutaneous manifestations such as maculopapular eruption, purpura, urticaria or erythroderma. Histhopatho­Iogy of lymphnodes has a characteristic picture. The etiology of AIL is unk...

Mycobacterial spindle cell pseudotumor (MSP) is a rare proliferation of spindle-shaped histiocytes that occurs most frequently in lymph nodes but has also been documented the skin, soft tissue, abdomen, and other sites. These lesions contain acid-fast mycobacteria, commonly Mycobacterium avium complex. Fewer than 10 cases cutaneous MSPs have published, occurred immunocompromised patients, eithe...

UNLABELLED Langerhans cell sarcoma (LCS) typically presents as cytologic atypia and clinical aggressiveness and may involve multiple organs during the progression of the disease. Primary skin LCS without any extra-cutaneous site association is extremely rare and only a few such cases have been described in the literature. We present a case of unusual primary LCS in skin occurring in a middle-ag...

Mutations in the three rat sarcoma (RAS) family members NRAS (neuroblastoma-RAS), HRAS (Harvey-RAS) and KRAS (Kirsten-RAS) are found in one third of human cancers. Among the first oncogenes discovered in cutaneous melanoma was NRAS, which is mutant in up to 20% of tumors causing aberrant signaling in several downstream cascades. Despite, being a highly relevant therapeutic target, design of sma...