Methotrexate-induced cutaneous ulceration has rarely been reported in patients with mycosis fungoides. We report 4 patients with mycosis fungoides who developed cutaneous ulceration as an initial manifestation of methotrexate toxicity. Methotrexate dose at the time of ulceration ranged from 10-60 mg. All 4 patients were erythrodermic, which may have predisposed them to this toxic effect. It is ...

Secondary syphilis has been known since the late 19th century as the great imitator; however, some experts now regard cutaneous lymphoma as the great imitator of skin disease. Either disease, at times an equally fastidious diagnosis, has reported to mimic each other even. It is thus vital to consider these possibilities when presented with a patient demonstrating peculiar skin lesions. No other...

Juvenile systemic lupus erythematosus (JSLE) is an autoimmune-mediated multiorgan disease. The cutaneous manifestation is one of the most common initial presentations in JSLE. A typical lesion is a facial malar rash, but a patient may sometimes present with nonclassical lesions. Herein, we report two cases of JSLE with similar persistent scaly ear rashes as the heralding cutaneous symptom prece...

Human mycoses represent infections with an increasing incidence and location due to the increasing number of favourable factors of occurrence such as prolonged and intensive antibiotic therapy, cytostatic therapy, corticosteroid therapy and suppressed immunity. Our study led to important conclusions regarding the incidence of different mycoses among different groups of age and between the two s...

Pseudolymphomatous folliculitis (PLF), which clinically mimicks cutaneous lymphoma, is a rare manifestation of cutaneous pseudolymphoma and cutaneous lymphoid hyperplasia. Here, we report on a 45-year-old Japanese woman with PLF. Dermoscopy findings revealed prominent arborizing vessels with small perifollicular and follicular yellowish spots and follicular red dots. A biopsy specimen also reve...

A 39-year-old man presented with a rapidly growing unilateral painless nodule on the right cheek. Histopathological examination and peripheral blood analysis both showed a population of T-cell large granular lymphocytes, which were CD1+, CD2+, CD5+, CD7+ and CD16+, with expression of cutaneous lymphocyte-associated antigen. Further laboratory examination revealed severe neutropaenia, relative l...

INTRODUCTION The incidence of cutaneous metastasis in patients with cancer is estimated to be 0.6% to 10.4%. In women, breast cancer is the most frequent primary malignancy metastasizing to the skin. A large study reported that cutaneous metastasis occurs in 23.9% of patients with breast carcinoma. Different patterns of cutaneous breast carcinoma metastasis have been described, including nodula...

For many years, to reduce the crash frequency and severity at high-speed signalized intersections, warning flashers have been used to alert drivers of potential traffic-signal changes. Recently, more aggressive countermeasures at such intersections include a speed-limit reduction in addition to warning flashers. While such speed-control strategies have the potential to further improve the crash...

WY Lam, FRCPath, FHKAM(Pathology) Cytomegalovirus (CMV) is a DNA virus belonging to the herpesvirus family. They replicate in the nucleus and form intranuclear inclusions and lead to giant cell formation. They have the ability to cause latent infection in humans. Reactivation from latency might occur in immunocompromised patients. It causes encephalitis, pneumonitis, colitis, retinitis and also...