Microscopic Polyangiitis (MPA) is an autoimmune disease characterized by pauci-immune, necrotizing, small-vessel vasculitis without clinical or pathological evidence of necrotizing granulomatous inflammation. Because many different organ systems may be involved, a wide range of symptoms are possible in MPA. Cutaneous involvement is not frequent. We describe a young girl who presented with multi...

We report a case of borderline lepromatous leprosy with chromoblastomycosis, in view of the rarity of such a clinical presentation and to highlight the coexistence of two granulomatous infections. Chromoblastomycosis presents as verrucous lesions that are usually localised to the skin and subcutaneous tissue, most commonly on the legs and feet, and may spread along lymphatics [causing elephanti...

We describe a palisaded granulomatous skin nodule containing bacterial rods, in a patient with rheumatoid arthritis (RA). The case emphasizes that fact that a known history of RA should not preclude submission of tissue for culture studies or careful histologic review for micro-organisms of any lesion that is interpreted as clinically and/or histologically consistent with a rheumatoid nodule. C...

A case is reported of an English woman who presented with a mass in the breast which was locally excised. Histological studies revealed a giant-cell granulomatous inflammation involving the duct system and a fungus showing brown pigmentation was demonstrated in the lesions. This was not grown in culture but the morphological appearance suggested classification in the genus Cladosporium. The rel...

Leprosy is a granulomatous disease that mainly affects the skin and peripheral nerves. It is caused by infection with mycobacterium leprae or mycobacterium lepromatosus. In most instances, diagnosis of leprosy can easily be made based on the clinical signs and symptoms. However, when patients present with atypical features, clinical diagnosis can be a challenge. We report a case of a nursing mo...

Sporotrichosis is a generally cutaneous, granulomatous, chronic and benign infection. Less frequently the disease may affect the joints. Articular involvement is usually characterized by monoarthritis in the absence of systemic symptoms, generally preceded by skin lesions, and frequently affects immunosuppressed individuals. We describe here the case of a healthy patient presenting knee arthrit...

It is presented a case of borderline lepromatous leprosy with 4 years of evolution and cutaneous lesions of difficult diagnosis in the National Health System. The histopathological evaluation, which was essential for the diagnosis, showed disorganized granulomatous structures and multiple alcohol -acid resistant bacilli. Cases like the one described here are responsible for the contamination of...

Nocardiosis is an opportunistic, localized or disseminated granulomatous infection caused by an aerobic actinomycete most commonly found in soil, decomposing vegetation, and other organic matter, as well as in fresh and salt water 1. Infection most commonly occurs through the respiratory tract. Manifestations of disease range from cutaneous infection caused by traumatic inoculation of the organ...

Leprosy is a chronic granulomatous infection, caused by mycobacterium leprae, primarily affecting the peripheral nerve trunks and cutaneous nerves. It classically presents with neural or dermal signs and symptoms. The indolent course of leprosy may manifest as erythema nodosum (appearance of tender inflamed subcutaneous nodule) and reversal reaction (inflammation in the previous skin lesion, ap...

Metastatic Crohn's disease is a rare skin manifestation, defined by granulomatous skin lesions that are discontinuous to the affected gastrointestinal tract and histopathologically resembling inflammatory bowel lesions. Up to 44% of patients with Crohn's disease have cutaneous manifestations, of which metastatic lesions are the least common. We present a case of an adolescent with refractory Cr...